Claudin Proteins And Neuronal Function.
Claudin Proteins And Neuronal Function.
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DOI：
10.1016/s1063-5823(10)65010-7
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发表时间：
2010
影响因子：
--
通讯作者：
Gow, Alexander
中科院分区：
文献类型：
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作者：
Devaux, Jerome;Fykkolodziej, Bozena;Gow, Alexander
20世纪90年代末，紧密连接蛋白(TJ)Claudin家族的鉴定和鉴定开创了细胞间连接的分子和细胞生物学研究的新纪元。从那时起，人们在许多疾病的背景下对TJ进行了研究，包括耳聋、男性不育症、癌症、细菌入侵以及肝肾疾病。在这篇综述中，我们讨论了Claudins在神经系统中的作用，重点讨论了神经胶质细胞中的TJ参与神经功能的机制。电生理学证据表明，Claudins可能以类似于极化上皮的方式在中枢神经系统(CNS)中工作。我们还评估了这样的假设，即TJ是免疫特权髓鞘的守门人，TJ在进化过程中出现，在髓鞘内形成了主要的粘附力。最后，我们考虑了中枢神经系统髓鞘TJ在行为障碍(精神分裂症)和脱髓鞘/髓鞘减少疾病(多发性硬化症和脑白质营养不良)的背景下的意义，并探索了白质异常患者情感障碍症状的可能机制的证据。
The identification and characterization of the claudin family of tight junction (TJ) proteins in the late 1990s ushered in a new era for research into the molecular and cellular biology of intercellular junctions. Since that time, TJs have been studied in the contexts of many diseases including deafness, male infertility, cancer, bacterial invasion and liver and kidney disorders. In this review, we consider the role of claudins in the nervous system focusing on the mechanisms by which TJs in glial cells are involved in neuronal function. Electrophysiological evidence suggests that claudins may operate in the central nervous system (CNS) in a manner similar to polarized epithelia. We also evaluate hypotheses that TJs are the gatekeepers of an immune-privileged myelin compartment and that TJs emerged during evolution to form major adhesive forces within the myelin sheath. Finally, we consider the implications of CNS myelin TJs in the contexts of behavioral disorders (schizophrenia) and demyelinating/hypomyelinating diseases (multiple sclerosis and the leukodystrophies), and explore evidence of a possible mechanism governing affective disorder symptoms in patients with white matter abnormalities.