Production of a colony‐stimulating factor following differentiation of leukemic myeloblasts to macrophages
Production of a colony‐stimulating factor following differentiation of leukemic myeloblasts to macrophages
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白血病成髓细胞分化为巨噬细胞后产生集落刺激因子
DOI：
10.1002/jcp.1041020307
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发表时间：
1980
影响因子：
5.6
通讯作者：
Y. Ichikawa
中科院分区：
文献类型：
--
作者：
M. Maeda;Y. Ichikawa
通过来自革兰氏阴性菌的脂多糖（LPS）诱导来自鼠髓性白血病细胞系（M1）的成髓细胞期白血病细胞分化为巨噬细胞。粒细胞-巨噬细胞集落刺激因子（CSF）仅在分化过程中产生。诱导分化后，LPS的持续存在是刺激巨噬细胞释放CSF所必需的。
Leukemic cells in the myeloblastic stage from a murine myeloid leukemia cell line (M1) were induced to differentiate to macrophages by lipopolysaccharide (LPS) from Gram‐negative bacteria. A granulocyte‐macrophage colony‐stimulating factor (CSF) was produced only during differentiation. After induction of differentiation, the continued presence of LPS was necessary to stimulate the macrophages to release CSF.