PEO coated magnetic nanoparticles for biomedical application
PEO coated magnetic nanoparticles for biomedical application
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DOI：
10.1016/j.eurpolymj.2008.07.011
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发表时间：
2008-10-01
影响因子：
6
通讯作者：
Jerome, C.
中科院分区：
文献类型：
--
作者：
Aqil, A.;Vasseur, S.;Jerome, C.
本文报道了超顺磁性纳米粒子（磁铁矿Fe 3 O 4）的制备、表征和隐身性，该纳米粒子直径为5 nm，在水（pH >= 6.5）中由水溶性聚环氧乙烷（PEO）链壳稳定。两种类型的二嵌段共聚物，即，制备了具有不同组成和分子量的聚（丙烯酸）-b-聚（环氧乙烷）（PAA-PEO）和聚（丙烯酸）-b-聚（丙烯酸酯甲氧基聚（环氧乙烷））（PAA-PAMPEO）作为稳定剂。在pH >= 6.5时，负离子化的PAA嵌段与带正电荷的纳米颗粒强烈相互作用，从而起到锚定嵌段的作用。通过动态光散射（DLS）和透射电子显微镜（TEM）实际观察到包覆纳米颗粒的聚集体。流体动力学直径在50-100 nm范围内，聚集数（每个聚集体的纳米颗粒数）在几十到几百之间。此外，通过溶血CH 50试验在“体外”评估这些聚集体的隐蔽性。没有观察到补体系统的响应，使得可以设想这些磁性纳米颗粒的生物医学应用。进行了磁加热（10 kA/m：108 kHz）的初步实验，比吸收率从2到13 W/g（（Fe））变化。(c)2008爱思唯尔有限公司保留所有权利。
This paper reports on the preparation, characterization and stealthiness of superparamagnetic nanoparticles (magnetite Fe3O4) with a 5 nm diameter and stabilized in water (pH >= 6.5) by a shell of water-soluble poly(ethylene oxide) (PEO) chains. Two types of diblock copolymers, i.e., poly(acrylic acid)-b-poly(ethylene oxide), PAA-PEO, and poly(acrylic acid)-b-poly(acrylate methoxy poly(ethyleneoxide)), PAA-PAMPEO, were prepared as stabilizers with different compositions and molecular weights. At pH >= 6.5, the negatively ionized PAA block interacts strongly with the positively-charged nanoparticles, thus playing the role of an anchoring block. Aggregates of coated nanoparticles were actually observed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The hydrodynamic diameter was in the 50-100 nm range and the aggregation number (number of nanoparticles per aggregate) was lying between several tens and hundred. Moreover, the stealthiness of these aggregates was assessed "in vitro" by the hemolytic CH50 test. No response of the complement system was observed, such that biomedical applications can be envisioned for these magnetic nanoparticles. Preliminary experiments of magnetic heating (10 kA/m: 108 kHz) were performed and specific absorption rate varied from 2 to 13 W/g((Fe)). (c) 2008 Elsevier Ltd. All rights reserved.