Functional development of the visual system in human fetus using magnetoencephalography
Functional development of the visual system in human fetus using magnetoencephalography
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DOI：
10.1016/j.expneurol.:2004.04.007
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发表时间：
2004-11-01
影响因子：
5.3
通讯作者：
Preissl, H
中科院分区：
文献类型：
--
作者：
Eswaran, H;Lowery, CL;Preissl, H
人脑在子宫内的发育通常被认为是一个动态过程，主要涉及神经元及其分布的结构和数量变化。然而，人们普遍认为，功能专门化的并行发展发生在大脑的某些区域，尤其是初级皮层。几乎所有有关胎儿大脑功能发育的知识都是从各种动物研究而不是人类研究中获得的。这些研究表明，听觉、视觉和体感皮层等主要感觉区域表现出与完全发育的大脑相似的基本功能。研究表明，视觉系统在胎儿时期发育，并在出生前发挥功能。几项研究证明了对早产儿使用视觉诱发反应（VER）记录来跟踪视觉系统功能发育的可行性。随着脑磁图 (MEG) 无创技术的出现，人类胎儿 VER 记录现在成为可能，从而提供了跟踪其妊娠期功能发育的机会。我们展示并讨论了使用 151 通道 MEG 系统从妊娠 28 周开始对人类胎儿进行 VER 记录的结果。 (C) 2004 Elsevier Inc. 保留所有权利。
The development of the human brain in utero is normally regarded as a dynamic process involving mainly structural and quantitative changes in neurons and their distribution. However, it is generally accepted that a parallel development of functional specialization occurs in certain areas of the brain, especially in the primary cortex. Nearly all knowledge of functional fetal brain development has been obtained from various animal studies rather than human studies. These studies show that the primary sensory areas like auditory, visual, and somatosensory cortex show a basic function similar to that of a fully developed brain. It has been specifically shown that the visual system develops during fetal life and becomes functional before birth. Several studies have demonstrated the feasibility of using visual evoked response (VER) recordings on preterm human infants to follow the functional development of the visual system. With the advent of the noninvasive technique of magnetoencephalography (MEG), human fetal VER recordings are now possible thus providing the opportunity to track its functional development with gestation. We present and discuss the results of VER recordings in human fetuses starting at 28 weeks of gestation performed using a 151-channel MEG system. (C) 2004 Elsevier Inc. All rights reserved.