Olfactory bulb volume in patients with temporal lobe epilepsy
Olfactory bulb volume in patients with temporal lobe epilepsy
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DOI：
10.1007/s00415-012-6741-x
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发表时间：
2013-04-01
影响因子：
6
通讯作者：
Haehner, Antje
中科院分区：
文献类型：
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作者：
Hummel, Thomas;Henkel, Sophia;Haehner, Antje
本研究旨在探讨颞叶癫痫（TLE）患者嗅球（OB）的体积。具体来说，我们想看看TLE患者中典型的嗅觉缺陷是否也会对OB产生自上而下的影响。20名患者和20名年龄和性别匹配的健康对照者通过嗅探棒测试装置进行嗅觉测试（测量气味阈值和识别能力）。此外，他们还接受了2毫米厚的t2加权快速自旋回波图像的磁共振扫描，冠状面无夹层间隙，覆盖颅骨基部的前段和中段。与健康对照组相比，TLE患者的嗅觉功能在阈值水平和气味识别方面均显著受损（p < 0.001）；此外，OB体积小于对照组（p = 0.013）。在OB水平上看到的缺陷与癫痫病灶的侧面无关。假设TLE患者的嗅觉缺陷是由中枢神经癫痫灶引起的，那么OB体积似乎不仅受嗅觉系统外周的变化影响，而且还受皮层水平变化的影响。
The study aimed to investigate the volume of the olfactory bulb (OB) in patients with temporal lobe epilepsy (TLE). Specifically, we wanted to see whether the olfactory deficit typically found in TLE patients also exerts a top-down influence on the OB. Twenty patients, and 20 age- and sex-matched healthy controls underwent olfactory testing by means of the Sniffin' Sticks testing device (measurement of odor threshold, and identification abilities). In addition, they underwent an MR scan with 2-mm-thick T2-weighted fast spin-echo images without interslice gap in the coronal plane covering the anterior and middle segments of the base of the skull. Olfactory function was significantly impaired in TLE patients compared to healthy controls both at threshold level and for odor identification (p < 0.001); in addition, OB volumes were smaller than in controls (p = 0.013). The deficit seen at the level of the OB did not correlate with the side of the epileptic focus. Assuming that the olfactory deficit in TLE patients is due to the central nervous epileptic focus it appears that the OB volume is not only subject to changes in the periphery of the olfactory system, but also changes as a consequence to changes at a cortical level.