Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction
Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction
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DOI：
10.3945/ajcn.110.007674
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发表时间：
2011-05-01
影响因子：
7.1
通讯作者：
Burgess, Shawn C.
中科院分区：
文献类型：
--
作者：
Browning, Jeffrey D.;Baker, Jonathan A.;Burgess, Shawn C.
背景：非酒精性脂肪性肝病（NAFLD）患者肝内甘油三酯过多。这部分是由于肝脏通过脂肪生成从碳水化合物合成脂肪的增加。虽然减肥是目前推荐的治疗NAFLD，很少有人注意到饮食碳水化合物restriction.Objective：本研究的目的是确定2周的饮食碳水化合物和热量限制在减少NAFLD受试者的肝脏甘油三酯的有效性。设计：18名NAFLD受试者（n = 5名男性和13名女性），平均（+/- SD）年龄为45 ± 12岁，体重指数（kg/m2）为35 ± 7，
Background: Individuals with nonalcoholic fatty liver disease (NAFLD) have excess intrahepatic triglycerides. This is due, in part, to increased hepatic synthesis of fat from carbohydrates via lipogenesis. Although weight loss is currently recommended to treat NAFLD, little attention has been given to dietary carbohydrate restriction.Objective: The aim of this study was to determine the effectiveness of 2 wk of dietary carbohydrate and calorie restriction at reducing hepatic triglycerides in subjects with NAFLD.Design: Eighteen NAFLD subjects (n = 5 men and 13 women) with a mean (+/- SD) age of 45 +/- 12 y and a body mass index (in kg/m(2)) of 35 +/- 7 consumed a carbohydrate-restricted (