Intermolecular N-Heterocyclic Carbene Catalyzed Hydroacylation of Arynes
Intermolecular N-Heterocyclic Carbene Catalyzed Hydroacylation of Arynes
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DOI：
10.1002/anie.201005490
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发表时间：
2010-01-01
影响因子：
16.6
通讯作者：
Glorius, Frank
中科院分区：
文献类型：
--
作者：
Biju, Akkattu T.;Glorius, Frank
正式介绍：概念上新的N-杂环卡宾催化芳炔正式插入醛的C甲酰基-H键中，证明了亲核NHC与亲电子芳炔的相容性。这种 NHC 催化的芳烃加氢酰化可以将脂肪族醛、α,β-不饱和醛和芳香醛转化为芳基酮；提供了 27 个示例和初步机制研究。
A formal introduction: The conceptually new N-heterocyclic carbene catalyzed formal insertion of arynes into the CformylH bond of aldehydes demonstrates the compatibility of nucleophilic NHCs with electrophilic arynes. This NHC-catalyzed hydroacylation of arynes allows the conversion of aliphatic, α,β-unsaturated, and aromatic aldehydes into aryl ketones; 27 examples and a preliminary mechanistic investigation are provided.