Additively manufactured metallic biomaterials.
Additively manufactured metallic biomaterials.
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DOI：
10.1016/j.bioactmat.2021.12.027
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发表时间：
2022-09
影响因子：
18.9
通讯作者：
Toyserkani E
中科院分区：
文献类型：
--
作者：
Davoodi E;Montazerian H;Mirhakimi AS;Zhianmanesh M;Ibhadode O;Shahabad SI;Esmaeilizadeh R;Sarikhani E;Toorandaz S;Sarabi SA;Nasiri R;Zhu Y;Kadkhodapour J;Li B;Khademhosseini A;Toyserkani E
金属增材制造（AM）已经导致硬组织替代物的设计和制造的发展，使个性化植入物能够满足每个患者的特定需求。此外，集成在增材制造的支架内的内部孔结构提供了进一步开发和设计功能性植入物以实现更好的组织整合和长期耐久性的机会。在这篇综述中，突出了增材制造金属生物材料的设计和制造的不同方面的最新进展。在介绍了金属AM工艺之后，提出了适于与AM机器集成的生物相容性金属。然后，我们详细介绍了设计具有工程内部结构的多孔支架的工具和方法，包括拓扑优化技术，以及基于晶格网络的单元格图案和三重周期最小表面。在这里，功能梯度多孔结构所带来的新的可能性，以满足冲突的支架设计要求进行了彻底的讨论。随后，根据输入参数（如设计特征和AM加工参数）审查增材制造结构的设计约束和物理特征。我们评估了增材制造植入物在不同组织类型再生中的拟议应用以及对其临床转化所做的努力。最后，我们总结了新兴的方向和前景，为进一步发展AM在医疗行业的审查。增材制造（AM）通过定制设计提供先进的金属植入物。本文综述了AM技术和金属植入物的设计方法。AM金属植入物可以优化以模拟硬组织。未来的方向是进一步从事AM的临床试验。
Metal additive manufacturing (AM) has led to an evolution in the design and fabrication of hard tissue substitutes, enabling personalized implants to address each patient's specific needs. In addition, internal pore architectures integrated within additively manufactured scaffolds, have provided an opportunity to further develop and engineer functional implants for better tissue integration, and long-term durability. In this review, the latest advances in different aspects of the design and manufacturing of additively manufactured metallic biomaterials are highlighted. After introducing metal AM processes, biocompatible metals adapted for integration with AM machines are presented. Then, we elaborate on the tools and approaches undertaken for the design of porous scaffold with engineered internal architecture including, topology optimization techniques, as well as unit cell patterns based on lattice networks, and triply periodic minimal surface. Here, the new possibilities brought by the functionally gradient porous structures to meet the conflicting scaffold design requirements are thoroughly discussed. Subsequently, the design constraints and physical characteristics of the additively manufactured constructs are reviewed in terms of input parameters such as design features and AM processing parameters. We assess the proposed applications of additively manufactured implants for regeneration of different tissue types and the efforts made towards their clinical translation. Finally, we conclude the review with the emerging directions and perspectives for further development of AM in the medical industry. Additive manufacturing (AM) has advanced metallic implants by customized design. This review discusses AM technologies and design approaches for metallic implants. AM metallic implants can be optimized to mimic hard tissues. Future directions are introduced to further engage AM in clinical trials.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.msec.2018.06.051
发表时间：
2018-11-01
影响因子：
7.9
作者：
Afshar, M.;Anaraki, A. Pourkamali;Montazerian, H.
通讯作者：
Montazerian, H.