AGED MONKEYS EXHIBIT BEHAVIORAL DEFICITS INDICATIVE OF WIDESPREAD CEREBRAL-DYSFUNCTION
AGED MONKEYS EXHIBIT BEHAVIORAL DEFICITS INDICATIVE OF WIDESPREAD CEREBRAL-DYSFUNCTION
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DOI：
10.1016/0197-4580(91)90048-o
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发表时间：
1991-03-01
影响因子：
4.2
通讯作者：
CORK, LC
中科院分区：
文献类型：
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作者：
BACHEVALIER, J;LANDIS, LS;CORK, LC
为了确定猴子的行为能力随年龄增长而下降是选择性的还是普遍的，我们对 18 只年龄从 3 岁到 34 岁的猴子进行了各种各样的测试，最终目标是将行为缺陷与大脑中与年龄相关的变化联系起来。 在我们最初的研究中，我们发现老年猴子的视觉识别能力受损 (43)。 在本研究中，我们对相同的动物进行了空间记忆、视觉习惯形成、视觉空间定向、视觉引导到达、运动技能学习和反应时间的测试，选择这些类别是为了测试不同大脑系统的完整性。 得出了三项主要发现。 首先，几乎在所有测试类别中都观察到了与年龄相关的障碍，尽管通常不是在简单版本的测试中，这表明观察到的缺陷是在测量的特定能力中，而不是动机降低或其他一般残疾的人为因素。 其次，某些空间能力的行为下降从十几岁开始，但直到二十多岁才影响其他能力，这表明虽然大脑功能障碍最终变得普遍，但空间能力背后的大脑系统比其他人更早因衰老而受到损害。 最后，主要在测试类别内而不是跨类别的老年动物得分之间的相关性发现表明，不同的动物具有不同的大脑参与模式。
To determine whether the decline of behavioral abilities with aging in monkeys is selective or widespread, we examined 18 monkeys ranging from 3 to 34 years of age on a wide variety of tests with the ultimate goal of correlating behavioral deficits with age-related changes in the brain. In our initial study we found impaired visual recognition ability in the aged monkeys (43). In the present study, we assessed the same animals on tests of spatial memory, visual habit formation, visuospatial orientation, visually gudied reaching, motor skill learning, and reaction time, these categories having been chosen to test the integrity of different cerebral systems. There were three major findings. First, age-related impairments were observed in nearly all test categories, though often not on easy versions of the tests, suggesting that the deficits observed were in the specific abilities measured and not an artifact of lowered motivation or other general disability. Second, the behavioral decline began in the late teens for certain spatial abilities but did not affect other abilities until the late 20's, suggesting that although the cerebral dysfunction eventually becomes widespread, the cerebral systems underlying spatial abilities are compromised by aging earlier than others. Finally, the finding of correlations between scores of aged animals primarily within tests categories as opposed to across categories suggests that different animals have different patterns of cerebral involvement.