IDENTIFICATION OF BMP-4 AS A SIGNAL MEDIATING SECONDARY INDUCTION BETWEEN EPITHELIAL AND MESENCHYMAL TISSUES DURING EARLY TOOTH DEVELOPMENT
IDENTIFICATION OF BMP-4 AS A SIGNAL MEDIATING SECONDARY INDUCTION BETWEEN EPITHELIAL AND MESENCHYMAL TISSUES DURING EARLY TOOTH DEVELOPMENT
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DOI：
10.1016/s0092-8674(05)80083-2
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发表时间：
1993-10-08
期刊：
影响因子：
64.5
通讯作者：
THESLEFF, I
中科院分区：
文献类型：
--
作者：
VAINIO, S;KARAVANOVA, I;THESLEFF, I
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Growth factor-mediated signaling has been implicated in the regulation of epithelial-mesenchymal interactions during organogenesis. Bone morphogenetic protein 4 (BMP-4), a member of the transforming growth factor beta superfamily, is expressed in the presumptive dental epithelium at the initiation of tooth development. Subsequently, epithelial signaling leads to mesenchymal induction of BMP-4 expression. To address the role of this factor, BMP-4-releasing agarose beads were added to dental mesenchyme in culture. These beads induced a translucent mesenchymal zone similar to that induced by dental epithelium. Moreover, three transcription factors (Msx-1, Msx-2, and Egr-1) whose expression is governed by epithelial signaling were induced in response to BMP-4. In addition, BMP-4 induced its own mesenchymal expression. These findings support the hypothesis that BMP-4 mediates epithelial-mesenchymal interactions during early tooth development.