CLINICAL-CRITERIA FOR VASCULAR DEMENTIA - THE NINDS-AIREN CRITERIA
CLINICAL-CRITERIA FOR VASCULAR DEMENTIA - THE NINDS-AIREN CRITERIA
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DOI：
10.1159/000106721
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发表时间：
1994-05-01
期刊：
影响因子：
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通讯作者：
ERKINJUNTTI, T
中科院分区：
文献类型：
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作者：
ERKINJUNTTI, T
血管性痴呆（VAD）是痴呆的第二常见原因。此外，脑血管疾病（CVD）与其他原因并存，包括阿尔茨海默病。与心血管疾病相关的认知障碍可能是可以预防的，这些患者可以从治疗中受益。这强调了 VAD 临床诊断的早期检测、诊断一致性和准确性的必要性。目前我们对 VAD 认识的一些局限性限制了临床标准的构建，特别是影响大脑的血管因素引起的行为综合征的概念，以及与 VAD 相关的主要病理生理因素。后者包括脑血管病变的类型、范围、部位和发生速度，以及脑病变与认知障碍之间的因果关系。不过，有关 VAD 的相关信息正在开始出现。 MNDS-AIREN VAD 研讨会试图通过定义 CVD 的后果和 VAD 综合征的标准来促进国际讨论和合作，以进行流行病学和临床研究。本文对概念、病理生理因素、当前概念障碍以及临床诊断标准进行了回顾。
Vascular dementia (VAD) is the second most common cause of dementia. In addition, cerebrovascular disease (CVD) coexists with other causes, including Alzheimer's disease. Cognitive impairment related to CVD may be preventable, and these patients could benefit from therapy. This emphasizes the need for early detection, diagnostic consistency and accuracy of the clinical diagnosis of VAD. A number of current limitations in our knowledge about VAD have restricted the construction of clinical criteria, especially the concept of a behavioral syndrome due to vascular factors affecting the brain, and the main pathophysiological factors related to VAD. The latter include the type, extent, location and tempo of vascular brain lesions, as well as the causality between brain lesions and cognitive impairment. However, relevant information on VAD is beginning to emerge. The MNDS-AIREN Workshop on VAD made an attempt to facilitate international discussion and cooperation by defining consequences of CVD and the criteria for the VAD syndrome, for epidemiological and clinical studies. Here the concepts, pathophysiological factors, current conceptual barriers, and the criteria for the clinical diagnosis are reviewed.