AUTISM AND AUTOIMMUNE DISEASE - FAMILY STUDY
AUTISM AND AUTOIMMUNE DISEASE - FAMILY STUDY
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DOI：
10.1007/bf01537954
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发表时间：
1971-01-01
期刊：
影响因子：
--
通讯作者：
CLARKE, FC
中科院分区：
文献类型：
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作者：
MONEY, J;BOBROW, NA;CLARKE, FC
提出了一个家庭，以证明罕见的现象，早期婴儿自闭症的自身免疫性疾病的存在。家里最小的儿子有多种自闭症、艾迪森氏病和念珠菌病的诊断。第二个哥哥患有甲状旁腺功能减退症、艾迪森氏病、念珠菌病和糖尿病。第二个哥哥患有甲状旁腺功能减退症、艾迪森氏病、念珠菌病和全脱发。这个四口之家的长子和第一个孩子和父母一样，没有任何症状。虽然最小的儿子的自闭症可能归因于创伤性的家庭环境，其中存在着持续的濒死威胁，但可以想象的是，它也可能归因于影响中枢神经系统的自身抗体的形成造成的自身免疫损伤的主要影响。
A family is presented to demonstrate the rare phenomenon of early infantile autism in the presence of autoimmune disease. The youngest son in the family has a multiple diagnosis of autism, Addison's disease, and moniliasis. The next older brother has hypoparathyroidism, Addison's disease, moniliasis, and diabetes mellitus. The next older brother has hypoparathyroidism, Addison's disease, moniliasis, and alopecia totalis. The oldest son and first born child in this family of four is, along with the parents, symptom free. Whereas autism in the youngest son might be attributed to the traumatic family situation, in which there exists the constant threat of near-death, it might conceivably be attributed also to a primary effect of autoimmune impairment from the formation of autoantibodies affecting the central nervous system.