Performance of modified Igls criteria to evaluate islet autograft function after total pancreatectomy with islet autotransplantation - a retrospective study.
Performance of modified Igls criteria to evaluate islet autograft function after total pancreatectomy with islet autotransplantation - a retrospective study.
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DOI：
10.1111/tri.13762
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Bellin MD
中科院分区：
文献类型：
--
作者：
McEachron KR;Yang Y;Hodges JS;Beilman GJ;Kirchner VA;Pruett TL;Chinnakotla S;Hering BJ;Bellin MD
Igls 标准根据 C 肽、胰岛素使用、血红蛋白 A1c 和严重低血糖来评估同种异体胰岛移植后的胰岛功能。然而，目前定义的这些标准不能应用于全胰切除胰岛自体移植（TPIAT）患者。我们在大型 TPIAT 患者队列 (n=379) 中测试了评估胰岛功能的修改标准。评估代谢结果。我们根据能力为每位患者分配 Auto-Igls 类别，并在 IAT 后 1 年评估 Auto-Igls 的实用性、有效性和围手术期风险因素。我们测试了 Auto-Igls 与胰岛移植功能的独立测量的关联，特别是连续血糖监测 (CGM) 数据或来自静脉内葡萄糖耐量测试的对葡萄糖的急性 C 肽反应 (ACRglu)。 264 名患者 (69%) 被分配为 Auto-Igls 类别。在无法分类的患者中，大多数都缺少准确的胰岛素剂量。 73% 的 TPIAT 接受者在 1 年时被评为最佳或良好。 Auto-Igls 类别的唯一显着预测因子是胰岛质量移植 (p<0.0001)。 Auto-Igls 类别与 CGM (p=0.02) 和 ACRglu (p<0.0001) 范围内 (70–140 mg/dL) 的时间百分比相关。 IAT 的改良 Igls 分类允许对 TPIAT 后的代谢结果进行简单、全面的评估，并与其他胰岛功能测量相关。
The Igls criteria assess islet function after islet allotransplant, based on C-peptide, insulin use, hemoglobin A1c, and severe hypoglycemia. However, these criteria as currently defined cannot be applied to total pancreatectomy islet autotransplant (TPIAT) patients. We tested modified criteria for assessing islet function in a large cohort TPIAT patients (n=379). Metabolic outcomes were assessed. We assigned Auto-Igls class to each patient as able and evaluated the utility, validity, and perioperative risk factors of Auto-Igls at 1 year post-IAT. We tested the association of Auto-Igls with independent measures of islet graft function, specifically continuous glucose monitoring (CGM) data or acute C-peptide response to glucose (ACRglu) from intravenous glucose tolerance tests. An Auto-Igls class was assigned to 264 patients (69%). Among patients who could not be classified, most were missing exact insulin dose. Seventy-three percent of TPIAT recipients were classified as optimal or good at 1 year. The only significant predictor of Auto-Igls class was islet mass transplanted (p<0.0001). Auto-Igls class was associated with percent time in range (70–140 mg/dL) on CGM (p=0.02) and ACRglu (p<0.0001). Modified Igls classification for IAT permits simple, comprehensive assessment of metabolic outcomes after TPIAT and is associated with other islet functional measures.
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影响因子：
8.2
作者：
Keskinen, P;Korhonen, S;Simell, O
通讯作者：
Simell, O
影响因子：
5.8
作者：
Bogachus, Lindsey D.;Bellin, Melena D.;Robertson, R. Paul
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影响因子：
7.7
作者：
Yoshimatsu, Gumpei;Kunnathodi, Faisal;Lawrence, Michael C.
通讯作者：
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影响因子：
3.4
作者：
Bellin MD;Blondet JJ;Beilman GJ;Dunn TB;Balamurugan AN;Thomas W;Sutherland DE;Moran A
通讯作者：
Moran A
DOI：
10.1016/j.jamcollsurg.2013.12.037
发表时间：
2014-04
影响因子：
5.2
作者：
Chinnakotla, Srinath;Radosevich, David M.;Dunn, Ty B.;Bellin, Melena D.;Freeman, Martin L.;Schwarzenberg, Sarah J.;Balamurugan, A. N.;Wilhelm, Josh;Bland, Barbara;Vickers, Selwyn M.;Beilman, Gregory J.;Sutherland, David E. R.;Pruett, Timothy L.
通讯作者：
Pruett, Timothy L.