A light-inducible Hedgehog signaling activator modulates proliferation and differentiation of neural cells.
A light-inducible Hedgehog signaling activator modulates proliferation and differentiation of neural cells.
复制标题
光诱导 Hedgehog 信号激活剂可调节神经细胞的增殖和分化。
DOI：
10.1021/acschembio.0c00195
复制
发表时间：
2020
影响因子：
4
通讯作者：
Yoshiho Ikeuchi.
中科院分区：
文献类型：
--
作者：
Ryuji Misawa;Tsuyoshi Minami;Akimitsu Okamoto;Yoshiho Ikeuchi.
Hedgehog信号通路通过调节细胞的增殖和分化来塑造我们的身体。其配体的时空分布模式精细地控制发育过程中Hedgehog途径的活性。为了在体外模拟Hedgehog信号传导活性的控制，我们开发了光诱导的Hedgehog信号传导激活剂6-硝基藜芦酰氧基-羰基Smoothened激动剂（NVOC-SAG）。NVOC-SAG以光依赖性方式控制小鼠小脑颗粒神经元前体细胞的增殖和人iPS细胞的腹侧和神经分化。该化合物提供了一种控制Hedgehog信号传导活性的新方法。
The Hedgehog signaling pathway shapes our body by regulating the proliferation and differentiation of cells. The spatial and temporal distribution pattern of its ligands finely controls the activity of the Hedgehog pathway during development. To model the control of Hedgehog signaling activities in vitro, we developed a light-inducible Hedgehog signaling activator 6-nitroveratryloxy-carbonyl Smoothened agonist (NVOC-SAG). NVOC-SAG controls the proliferation of mouse cerebellar granule neuron precursor cells and ventral and neural differentiation of human iPS cells in a light dependent manner. The compound provides a new method to control Hedgehog signaling activities.