Porphyrin-based porous organic frameworks as oxygen reservoirs to overcome tumor hypoxia for enhanced photodynamic therapy.
Porphyrin-based porous organic frameworks as oxygen reservoirs to overcome tumor hypoxia for enhanced photodynamic therapy.
复制标题
基于卟啉的多孔有机框架作为储氧克服肿瘤缺氧以增强光动力治疗
DOI：
10.1002/adtp.201900059
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发表时间：
2018
影响因子：
4.6
通讯作者：
Chunshun Zhao
中科院分区：
文献类型：
--
作者：
Gaofei Wei;Liangfeng Huang;Yifeng Shen;Zeqian Huang;Xiaoyu Xu;Chunshun Zhao
光动力疗法通过将能量从激光转移到肿瘤溶解的O2，使用光敏剂产生高细胞毒性活性氧来杀死癌细胞。然而，PDT的有效性受到光敏剂聚集和肿瘤中氧气供应不足的影响。为了克服上述局限性，本文报道了利用光敏剂卟啉作为结构单元通过亚胺缩合反应连接的新型多孔有机框架（POFs）。TAPP-B4-POFs兼具高孔隙率和大比表面积的特点，具有优异的载氧性能。O2 @ TAPP-B4-POFs携带O2后，在常氧和低氧环境下都能产生活性氧，诱导癌细胞凋亡。此外，在4 T1小鼠乳腺癌模型上的抗肿瘤实验表明，O2 @ TAPP-B4-POFs几乎可以完全抑制肿瘤进展，具有良好的安全性。这些结果表明，基于光敏剂的POFs材料是有希望的候选者，作为氧库，以克服肿瘤缺氧，用于增强光动力治疗。
Photodynamic therapy kills cancer cells by transferring energy from lasers to tumor‐dissolved O2to generate highly cytotoxic reactive oxygen species using a photosensitizer. However, the effectiveness of PDT is impaired by the aggregation of photosensitizer and an inadequate oxygen supply in tumors. Here, to overcome above limitations, novel porous organic frameworks (POFs) are reported using photosensitizer porphyrin as building blocks connected through imine condensation reactions. Upon both characteristic with the high porosity and the large surface area, TAPP‐B4‐POFs exhibit excellent O2carrying capacity. After carrying O2, O2@TAPP‐B4‐POFs generate ROS efficiency in both normoxic and hypoxic environment, which can induce cancer cell apoptosis. Moreover, the antitumor experiment on 4T1 murine breast cancer model demonstrates that O2@TAPP‐B4‐POFs can almost completely suppress tumor progression with good security. These results reveal that photosensitizer‐based POFs materials are promising candidates as oxygen reservoirs to overcome tumor hypoxia for enhanced photodynamic therapy.