Effect of cervical spinal cord stimulation on cerebral glucose metabolism
Effect of cervical spinal cord stimulation on cerebral glucose metabolism
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DOI：
10.1179/174313208x305373
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发表时间：
2008-07-01
影响因子：
1.9
通讯作者：
Carreras, Jose L.
中科院分区：
文献类型：
--
作者：
Clavo, Bernardino;Robaina, Francisco;Carreras, Jose L.
由Maney出版(C)W.S.Maney&son Limited出版目的：由脑血流和代谢活动减少引起的综合征具有重大的临床和社会影响。然而，治疗选择是有限的。颈髓刺激在几种缺血综合征的治疗中显示出临床益处。本研究旨在探讨颈髓刺激对脑葡萄糖代谢的影响。材料与方法：自2000年4月至2005年12月，对16例脑肿瘤患者进行研究。结果：颈髓刺激后，健康大脑半球的葡萄糖代谢显著增加(p<；0.001)。测量的增长为37.7%，估计第一(18)氟-2-脱氧葡萄糖注射剂对第二次正电子发射断层扫描研究(结转效应)的量化有潜在的最大贡献。
Published by Maney Publishing (c) W. S. Maney & Son Limited Objective: Syndromes resulting from decreased cerebral blood flow and metabolic activity have significant clinical and social repercussion. However, treatment options are limited. Cervical spinal cord stimulation has shown clinical benefit in the management of several ischemic syndromes. The aim of this report was to assess the effect of cervical spinal cord stimulation on cerebral glucose metabolism.Materials and methods: Between April 2000 and December 2005, 16 patients with brain tumors were assessed. Before and during spinal cord stimulation, they had cerebral glucose metabolism evaluated using (18)fluoro-2-deoxyglucose positron emission tomography ((18)FDG-PET) in the healthy cerebral hemisphere contralateral to the lesion area.Results: Following cervical spinal cord stimulation, there was a significant (p < 0.001) increase in glucose metabolism in healthy cerebral hemisphere. The measured increase was 37.7%, with an estimated potential maximal contribution of the first (18)fluoro-2-deoxyglucose injection to the quantification of the second positron emission tomography study (carry-over effect)