Correlation of structure and function in idiopathic pulmonary fibrosis.
Correlation of structure and function in idiopathic pulmonary fibrosis.
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特发性肺纤维化结构与功能的相关性。
DOI：
10.1164/ajrccm/151.4.1180
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
KingJr,TE
中科院分区：
文献类型：
--
作者：
Cherniack,RM;Colby,TV;Flint,A;Thurlbeck,WM;WaldronJr,JA;Ackerson,L;Schwarz,MI;KingJr,TE
特发性肺纤维化（IPF）的早期阶段被认为涉及较少数量的肺泡，并且主要特征为细胞性和最小的纤维化，而晚期疾病涉及大量的肺泡，并且主要特征为具有最小细胞性的纤维化。此外，相关研究表明，预后和治疗反应部分取决于纤维化和细胞结构的程度。本研究的目的是确定肺功能评估是否有助于区分这种疾病的细胞期和纤维化期，这是通过半定量病理学评分系统确定的，该系统包括四个因素评分：纤维化、细胞结构、肉芽/结缔组织和脱屑。对 96 名未经治疗且经活检确诊为 IPF 的患者（27 名从不吸烟者、32 名当前吸烟者和 37 名戒烟者）进行了评估。在整个组中，纤维化或结缔/肉芽组织因子评分与任何生理参数之间没有显着关系。 DLCO 与“脱屑”和总病理评分相关，而 TLC 和 FVC 与细胞因子评分相关。当前吸烟者的弹性回缩系数、DLCO/VA、FEV1/FVC比值显着低于从不吸烟者和戒烟者，TLC和FVC高于从不吸烟者。此外，平均细胞结构和肉芽/结缔组织因子得分显着低于从不吸烟者和戒烟者，而脱屑因子得分显着高于从不吸烟者和戒烟者。年龄和吸烟状况对于细胞因子评分均显着，而对于结缔/肉芽组织因子评分，年龄不显着，但吸烟状况显着。（摘要截断为 250 字）
The early stage of idiopathic pulmonary fibrosis (IPF) is thought to involve a smaller number of alveoli and to be characterized predominantly by cellularity and minimal fibrosis, whereas advanced disease involves a large number of alveoli and is characterized predominantly by fibrosis with minimal cellularity. In addition, correlative studies have indicated that prognosis and response to therapy is determined in part by the extent of fibrosis and cellularity. This study was undertaken to determine whether pulmonary function assessment would help distinguish between the cellular and fibrotic phases of this disorder, as determined by a semiquantitative pathology scoring system that comprised four factor scores: fibrosis, cellularity, granulation/connective tissue, and desquamation. Ninety-six untreated patients with biopsy-confirmed IPF (27 never smokers, 32 current smokers, and 37 ex-smokers) were evaluated. In the group as a whole, there was no significant relationship between the fibrosis or the connective/granulation tissue factor scores and any of the physiologic parameters. The DLCO correlated with the "desquamation" and the total pathology scores, whereas the TLC and FVC correlated with the cellularity factor score. In the current smokers, the coefficient of elastic retraction, DLCO/VA, and FEV1/FVC ratio were significantly lower than in never smokers and ex-smokers, and TLC and FVC were higher than in never smokers. Also, the mean cellularity and granulation/connective tissue factor scores were significantly lower, and the desquamation factor score was significantly higher than those in never smokers and ex-smokers. Both age and smoking status were significant for the cellularity factor score, whereas for the connective/granulation tissue factor score, age was not significant but smoking status was.(ABSTRACT TRUNCATED AT 250 WORDS)