Gabapentin for the treatment of neuropathic pain in a pregnant horse
Gabapentin for the treatment of neuropathic pain in a pregnant horse
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DOI：
10.2460/javma.231.5.755
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发表时间：
2007-09-01
影响因子：
1.9
通讯作者：
Elce, Yvonne
中科院分区：
文献类型：
--
作者：
Davis, Jennifer L.;Posner, Lysa P.;Elce, Yvonne
病例描述-一个24岁的732公斤（1，610磅）的怀孕比利时草案母马发展神经病变和顽固性疼痛的迹象后绞痛surgery.Clinical Findings恢复后绞痛手术治疗压缩的小肠和大肠，因为一个大胎儿，母马被注意到有股神经病变的迹象，涉及左后肢。在恢复后36小时内，母马出现了对常规治疗无反应的严重疼痛体征。没有发现胃肠道或肌肉异常，不适归因于神经性pain.Treatment和结局-母马用加巴喷丁（2.5 mg/kg [1.1 mg/lb]，PO，q12 h）治疗。在开始这种治疗后不久，母马看起来很舒服，不再有疼痛的迹象。给药持续6天，在此期间剂量逐渐降低，母马出院。临床相关性-加巴喷丁似乎是一种安全，有效，经济的治疗神经性疼痛，在这匹马。
Case Description-A 24-year-old 732-kg (1,610-lb) pregnant Belgian draft horse mare developed neuropathy and signs of intractable pain following colic surgery.Clinical Findings-Following recovery from colic surgery to treat compression of the small and large intestines because of a large fetus, the mare was noticed to have signs of femoral neuropathy involving the left hind limb. Within 36 hours after recovery, the mare developed signs of severe pain that were unresponsive to conventional treatment. No gastrointestinal tract or muscular abnormalities were found, and the discomfort was attributed to neuropathic pain.Treatment and Outcome-The mare was treated with gabapentin (2.5 mg/kg [1.1 mg/lb], PO, q 12 h). Shortly after this treatment was initiated, the mare appeared comfortable and no longer had signs of pain. Treatment was continued for 6 days, during which the dosage was progressively decreased, and the mare was discharged. The mare subsequently delivered a healthy foal.Clinical Relevance-Gabapentin appeared to be a safe, effective, and economical treatment for neuropathic pain in this horse.