THE EFFICIENCY OF MALE-TO-FEMALE AND FEMALE-TO-MALE SEXUAL TRANSMISSION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS - A STUDY OF 730 STABLE COUPLES
THE EFFICIENCY OF MALE-TO-FEMALE AND FEMALE-TO-MALE SEXUAL TRANSMISSION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS - A STUDY OF 730 STABLE COUPLES
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DOI：
10.1097/00001648-199411000-00003
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发表时间：
1994-11-01
期刊：
影响因子：
5.4
通讯作者：
ZERBONI, R
中科院分区：
文献类型：
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作者：
NICOLOSI, A;LEITE, MLC;ZERBONI, R
为了比较人类免疫缺陷病毒(HIV)在男性与女性之间和女性与男性之间的性传播效率，我们研究了16个意大利临床中心的524名艾滋病毒感染者的女性伴侣和206名艾滋病毒感染者的男性伴侣。所有的性伴侣都有性关系，指示病例持续至少6个月，除了与感染艾滋病毒的伴侣发生性关系外，没有其他危险因素。在730对夫妇中，24%的女性伴侣艾滋病毒阳性，而男性伴侣的这一比例为10%。经Logistic回归分析，包括性别和避孕套使用控制、性交次数、肛交次数、配偶的CD4(+)细胞计数和临床分期、性传播疾病、生殖器感染和避孕措施的使用，男性向女性传播的效率是女性向男性传播的2.3倍(95%可信区间=1.1~4.8)。接触表面的性别差异和性交期间接触艾滋病毒的强度可能是传播效率不同的原因。
To compare the efficiency of male-to-female and female-to-male sexual transmission of human immunodeficiency virus (HIV), we studied 524 female partners of HIV infected men and 206 male partners of HIV-infected women in 16 Italian clinical centers. All of the partners had had a sexual relarion ship with the index case lasting for at least 6 months and presented no other risk factor than sexual exposure to the HIV-infected partner. Among the 730 couples, 24% of the female partners were HIV positive, in comparison with 10% of the male partners. Using logistic regression analysis, including gender and controlling for condom use, frequency of intercourse, anal sex, partner's CD4(+) cell count and clinical stage, sexually transmitted diseases, genital infections, and contraceptive use, we found that the efficiency of male-to-female transmission was 2.3 (95% confidence interval = 1.1-4.8) times greater than that of female-to-male transmission. Between-gender differences in the contact surfaces and the intensity of exposure to HIV during sexual intercourse are possible reasons for the difference in efficiency of transmission.