Buprenorphine in Neonatal Abstinence Syndrome.

Buprenorphine in Neonatal Abstinence Syndrome.
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DOI:
10.1002/cpt.930
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发表时间:
2018-01
影响因子:
6.7
通讯作者:
Kraft WK
Kraft WK
中科院分区:
医学2区
文献类型:
--
作者:
Kraft WK

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Infants exposed in utero to opioids will demonstrate a withdrawal syndrome known as neonatal abstinence syndrome (NAS). Buprenorphine is a long-acting opioid with therapeutic use in medication-assisted treatment of opioid dependency in adults and adolescents. Emerging data from clinical trials and treatment cohorts demonstrate the efficacy and safety of sublingual buprenorphine for those infants with NAS who require pharmacologic treatment. Pharmacometric modeling will assist in defining the exposure–response relationships and facilitate dose optimization.
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