Crosstalk Between Trophoblasts and Decidual Immune Cells: The Cornerstone of Maternal-Fetal Immunotolerance.
Crosstalk Between Trophoblasts and Decidual Immune Cells: The Cornerstone of Maternal-Fetal Immunotolerance.
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滋养细胞和蜕膜免疫细胞之间的串扰：母胎免疫耐受的基石
DOI：
10.3389/fimmu.2021.642392
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发表时间：
2021
影响因子：
7.3
通讯作者：
Du M
中科院分区：
文献类型：
--
作者：
Xu L;Li Y;Sang Y;Li DJ;Du M
The success of pregnancy relies on the fine adjustment of the maternal immune system to tolerate the allogeneic fetus. Trophoblasts carrying paternal antigens are the only fetal-derived cells that come into direct contact with the maternal immune cells at the maternal–fetal interface. The crosstalk between trophoblasts and decidual immune cells (DICs) via cell–cell direct interaction and soluble factors such as chemokines and cytokines is a core event contributing to the unique immunotolerant microenvironment. Abnormal trophoblasts–DICs crosstalk can lead to dysregulated immune situations, which is well known to be a potential cause of a series of pregnancy complications including recurrent spontaneous abortion (RSA), which is the most common one. Immunotherapy has been applied to RSA. However, its development has been far less rapid or mature than that of cancer immunotherapy. Elucidating the mechanism of maternal–fetal immune tolerance, the theoretical basis for RSA immunotherapy, not only helps to understand the establishment and maintenance of normal pregnancy but also provides new therapeutic strategies and promotes the progress of immunotherapy against pregnancy-related diseases caused by disrupted immunotolerance. In this review, we focus on recent progress in the maternal–fetal immune tolerance mediated by trophoblasts–DICs crosstalk and clinical application of immunotherapy in RSA. Advancement in this area will further accelerate the basic research and clinical transformation of reproductive immunity and tumor immunity.
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影响因子：
2
作者：
Eskandarian, Maryam;Moazzeni, Seyed Mohammad
通讯作者：
Moazzeni, Seyed Mohammad
影响因子：
9.8
作者：
Brosens, Ivo;Puttemans, Patrick;Benagiano, Giuseppe
通讯作者：
Benagiano, Giuseppe
影响因子：
8.3
作者：
Care, Alison S.;Bourque, Stephane L.;Davidge, Sandra T.
通讯作者：
Davidge, Sandra T.
影响因子：
1.5
作者：
Farrokhi, Amir Salek;Zarnani, Amir-Hassan;Moazzeni, Seyed Mohammad
通讯作者：
Moazzeni, Seyed Mohammad
影响因子：
3.4
作者：
Abumaree, M. H.;Chamley, L. W.;El-Muzaini, M. F.
通讯作者：
El-Muzaini, M. F.