Identification and Evaluation of Antiepileptic Activity of C21 Steroidal Glycosides from the Roots of Cynanchum wilfordii
Identification and Evaluation of Antiepileptic Activity of C21 Steroidal Glycosides from the Roots of Cynanchum wilfordii
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DOI：
10.1021/acs.jnatprod.5b00766
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发表时间：
2016-01-01
影响因子：
5.1
通讯作者：
Zhao, Wei-Min
中科院分区：
文献类型：
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作者：
Li, Jin-Long;Gao, Zhao-Bing;Zhao, Wei-Min
从Cynanchum wilfordii的根中分离到9个新的C-21甾体苷类化合物，命名为cynawilfosides A-I（1-9）。通过光谱分析和化学方法对新化合物的结构进行了鉴定。五种主要成分犬牙菊苷A(1)、犬牙菊苷A（11）、犬牙菊苷C1N（16）、犬牙菊苷K1N（17）和犬牙菊苷G（18）在最大电休克（MES）小鼠癫痫模型中表现出显著的保护作用，ED50值分别为48.5、95.3、124.1、72.3和88.1 mg/kg。
Nine new C-21 steroidal glycosides, named cynawilfosides A-I (1-9), along with 12 known compounds were isolated from the roots of Cynanchum wilfordii. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The five major components, cynawilfoside A (1), cynauricoside A (11), wilfoside C1N (16), wilfoside K1N (17), and cyanoauriculoside G (18), exhibited significant protection activity in a maximal electroshock (MES)-induced mouse seizure model with ED50 values of 48.5, 95.3, 124.1, 72.3, and 88.1 mg/kg, respectively.