Explicit memory creation during sleep demonstrates a causal role of place cells in navigation
Explicit memory creation during sleep demonstrates a causal role of place cells in navigation
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DOI：
10.1038/nn.3970
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发表时间：
2015-04-01
影响因子：
25
通讯作者：
Benchenane, Karim
中科院分区：
文献类型：
--
作者：
de lavilleon, Gaetan;Lacroix, Marie Masako;Benchenane, Karim
海马体位置细胞群被认为支持认知地图，它们在睡眠时的重新激活被认为与空间记忆巩固有关。通过在睡眠中触发位置细胞尖峰的颅内奖励刺激，我们诱导了外显记忆痕迹，导致了对位置场的目标导向行为。这表明，位置细胞在睡眠期间的活动仍然传递着相关的空间信息，这种活动对导航具有重要的功能。
Hippocampal place cells assemblies are believed to support the cognitive map, and their reactivations during sleep are thought to be involved in spatial memory consolidation. By triggering intracranial rewarding stimulations by place cell spikes during sleep, we induced an explicit memory trace, leading to a goal-directed behavior toward the place field. This demonstrates that place cells' activity during sleep still conveys relevant spatial information and that this activity is functionally significant for navigation.