Exploratory activity, anxiety, and motor coordination in bigenic APPswe+PS1/ΔE9 mice
Exploratory activity, anxiety, and motor coordination in bigenic APPswe+PS1/ΔE9 mice
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DOI：
10.1016/j.neulet.2004.07.069
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发表时间：
2004-10-14
影响因子：
2.5
通讯作者：
Fukuchi, K
中科院分区：
文献类型：
--
作者：
Lalonde, R;Kim, HD;Fukuchi, K
在测量探索活动的三项测试中，对新皮质和海马中形成 Abeta 斑块的 Bigenic APPswc + PS1/DeltaE9 小鼠进行了评估。与控制年龄和性别的非转基因组相比，7 个月大的 APPswe + PS1/DeltaE9 小鼠在张开臂中花费更多时间，并且在高架十字迷宫中具有更高的开放/总条目和持续时间，表明去抑制倾向。相反，各组在 T 迷宫和旷场测试中没有差异。此外，在固定横梁、衣架、旋转杆和握力测试中，双基因组的运动协调性与对照组相当。没有小鼠表现出神经系统症状，如病理反射、肌阵挛或惊厥。高架十字迷宫测试的结果类似于在一些阿尔茨海默病患者中观察到的抑制控制丧失。 (C) 2004 Elsevier Ireland Ltd. 保留所有权利。
Bigenic APPswc + PS1/DeltaE9 mice with Abeta plaque formation in neocortex and hippocampus were evaluated in three tests measuring exploratory activity. By comparison to a non-transgenic group controlled for age and gender, 7-month-old APPswe + PS1/DeltaE9 mice spent more time in the open arms and had higher open/total entries and duration in the elevated plus-maze, indicative of disinhibitory tendencies. On the contrary, the groups did not differ in T-maze and open-field tests. Moreover, the motor coordination of the bigenic group was equivalent to that of controls in stationary beam, coat-hanger, rotorod, and grip strength tests. No mouse displayed neurological signs, such as pathological reflexes, myoclonus, or convulsions. The results in the elevated plus-maze test are akin to the loss of inhibitory control observed in some patients with Alzheimer's disease. (C) 2004 Elsevier Ireland Ltd. All rights reserved.