Effects of transcranial electrical stimulation on episodic memory in physiological and pathological ageing
Effects of transcranial electrical stimulation on episodic memory in physiological and pathological ageing
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DOI：
10.1016/j.arr.2020.101065
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发表时间：
2020-04
影响因子：
13.1
通讯作者：
Marco Sandrini;R. Manenti;Hakan Sahin;M. Cotelli
中科院分区：
文献类型：
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作者：
Marco Sandrini;R. Manenti;Hakan Sahin;M. Cotelli
对个人相关过去事件的记忆（情景记忆）对日常生活活动至关重要。这种类型的陈述性长期记忆的下降是健康老龄化的共同特征，这一过程在轻度认知障碍（MCI）和阿尔茨海默病（AD）患者中加速。经颅电刺激（tES）已被用作改善情景记忆的策略。在这里，我们批判性地回顾研究tES是否可以改善生理和病理老化的情景记忆。大多数研究表明，tES在前额叶或颞顶皮层可以有积极的影响情景记忆，但转移到改善日常生活活动的执行仍然是未知的。需要进一步的工作来更好地理解刺激作用的机制，将联合收割机tES与神经成像结合起来，并优化刺激的剂量。未来的研究还应探讨刺激的最佳时机以及与药物的组合，以诱导病理性衰老的长期有益效果。应进行更多的开放科学努力，以提高tES在衰老研究中的严谨性和可靠性。
Memory for personally-relevant past events (episodic memory) is critical for activities of daily living. Decline in this type of declarative long-term memory is a common characteristic of healthy ageing, a process accelerated in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD).Transcranial electrical stimulation (tES) has been used as a strategy to ameliorate episodic memory. Here, we critically review studies investigating whether tES may improve episodic memory in physiological and pathological ageing.Most of the studies suggest that tES over the prefrontal or temporoparietal cortices can have a positive effect on episodic memory, but the transfer to improvement of execution of daily living activities is still unknown. Further work is needed to better understand the mechanisms underlying the effects of stimulation, combine tES with neuroimaging and optimizing the dosing of stimulation. Future studies should also investigate the optimal timing of stimulation and the combination with medications to induce long-lasting beneficial effects in pathological ageing.More open science efforts should be done to improve rigor and reliability of tES in ageing research.