Optic neuropathy from metastatic squamous cell carcinoma of the cervix: an unusual CNS presentation.
Optic neuropathy from metastatic squamous cell carcinoma of the cervix: an unusual CNS presentation.
复制标题
宫颈转移性鳞状细胞癌引起的视神经病变：一种不寻常的中枢神经系统表现。
DOI：
10.1016/j.ygyno.2006.01.040
复制
发表时间：
2006
影响因子：
4.7
通讯作者：
D. Armstrong
中科院分区：
文献类型：
--
作者：
C. Portera;R. Gottesman;Monica Srodon;F. Asrari;M. Dillon;D. Armstrong
子宫颈癌的中枢神经系统（CNS）转移是罕见的事件。子宫颈鳞状细胞癌累及软脑膜尚未被广泛描述。CASEA 43岁女性，30岁时首次诊断为IB期子宫颈鳞状细胞癌，行子宫切除术和左侧输卵管卵巢切除术。她在39岁时复发淋巴结疾病，并在化疗和放疗后进入临床完全缓解。三年后，她出现了视神经病变的症状。脑脊液（CSF）鳞状细胞阳性，与原发性宫颈鳞状细胞癌一致。没有可测量的疾病是明显的以外的cns.CONCLUSIONMeningeal癌病从宫颈鳞状细胞癌涉及视神经尚未报道。该患者CNS转移性疾病的快速进展表明这种形式的转移可能更具侵袭性，预后极差。
BACKGROUNDCentral nervous system (CNS) metastases from cervical carcinoma are uncommon events. Leptomeningeal involvement from cervical squamous cell carcinoma has not been extensively described.CASEA 43-year-old woman with initial diagnosis of stage IB squamous cervical carcinoma at age 30 was treated with hysterectomy and left salpingo-oophorectomy. She recurred with nodal disease at age 39 and went into a clinical complete remission after chemotherapy and radiation treatment. Three years later, she presented with symptoms of optic neuropathy. Cerebral spinal fluid (CSF) was positive for squamous cells consistent with primary cervical squamous cell carcinoma. No measurable disease was evident outside of the CNS.CONCLUSIONMeningeal carcinomatosis from cervical squamous cell carcinoma involving optic nerves has not been reported. Rapid progression of this patient's CNS metastatic disease suggests this form of metastases may be more aggressive and carry extremely poor prognosis.