iroquois: A prepattern gene that controls the formation of bristles on the thorax of Drosophila
iroquois: A prepattern gene that controls the formation of bristles on the thorax of Drosophila
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DOI：
10.1016/0925-4773(96)00577-1
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发表时间：
1996-09-01
影响因子：
2.6
通讯作者：
DamblyChaudiere, C
中科院分区：
文献类型：
--
作者：
Leyns, L;GomezSkarmeta, JL;DamblyChaudiere, C
我们已经分离出一种果蝇突变体，其背的侧面部分完全裸露，留下不受影响的中间条纹的毛。这种突变，易洛魁人（ire），定义了一个新的基因，定位在69 D。我们发现，在假定的突变光盘的侧背，感觉器官前体细胞未能形成和proneural基因scute不表达。在iro附近插入的报告基因的表达表明iro本身在椎间盘的这个区域大量表达。我们认为iro是一个前模式基因，它对激活形成侧背的椎间盘区域中scute的表达至关重要。
We have isolated a Drosophila mutant where the lateral parts of the notum are completely naked, leaving unaffected a median stripe of hairs. This mutation, iroquois (ire), defines a new gene which maps at 69D. We show that, in the presumptive lateral notum of mutant discs, sense organ precursor cells fail to form and the proneural gene scute is not expressed. The expression of a reporter gene inserted near iro suggests that iro itself is massively expressed in this region of the disc. We propose that iro is a prepattern gene essential to activate the expression of scute in the regions of the disc that will form the lateral notum.