THE PATHOLOGY OF HEPATITIS-C
THE PATHOLOGY OF HEPATITIS-C
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DOI：
10.1002/hep.1840150402
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发表时间：
1992-04-01
期刊：
影响因子：
13.5
通讯作者：
DUSHEIKO, GM
中科院分区：
文献类型：
--
作者：
SCHEUER, PJ;ASHRAFZADEH, P;DUSHEIKO, GM
为了确定丙型肝炎的组织学模式，研究人员对来自 45 名临床病理诊断为丙型肝炎的患者的 54 份肝活检标本进行了研究。 通过第二代检测，所有患者的丙型肝炎病毒抗体血清呈阳性。 输血相关病例和散发病例均包括在内。 超过一半的样本显示没有肝硬化的慢性肝炎，而 44% 的样本显示正在发展或完全形成肝硬化。 在许多患者中发现了轻度慢性肝炎的组织学模式，伴有门静脉滤泡和不同程度的小叶活动。 78% 的活检标本中可见淋巴聚集体或滤泡，但在乙型肝炎患者的 27 份样本中的 14 份 (52%) 中也发现了聚集体，但不像丙型肝炎那么明显。我们得出的结论是，慢性丙型肝炎中存在一种特征性的组织学模式，这种模式并不总是被发现，而且突出的淋巴滤泡虽然不是丙型肝炎所独有，但提供了有用的诊断线索。
To determine the histologic pattern of hepatitis C, 54 liver biopsy specimens from 45 patients with a clinicopathological diagnosis of hepatitis C were studied. All patients were seropositive for antibody to hepatitis C virus by second-generation testing. Both transfusion-related and sporadic cases were included. More than half the samples showed chronic hepatitis without cirrhosis, whereas 44% showed developing or fully established cirrhosis. A histological pattern of mild chronic hepatitis with portal lymphoid follicles and varying degrees of lobular activity was found in many of the patients. Lymphoid aggregates or follicles were seen in 78% of biopsy specimens, but aggregates, less prominent than in hepatitis C, were also seen in 14 of 27 samples (52%) from patients with hepatitis B. We conclude that a characteristic histological pattern exists in chronic hepatitis C, that this pattern is not always found and that prominent lymphoid follicles, though not unique to hepatitis C, provide a useful diagnostic clue.