Nano nickel oxide modified non-enzymatic glucose sensors with enhanced sensitivity through an electrochemical process strategy at high potential
Nano nickel oxide modified non-enzymatic glucose sensors with enhanced sensitivity through an electrochemical process strategy at high potential
复制标题
纳米氧化镍修饰的非酶葡萄糖传感器通过高电位电化学工艺策略提高灵敏度
DOI：
10.1016/j.bios.2010.11.042
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发表时间：
2011-02-15
影响因子：
12.6
通讯作者：
Wu, Hai-Long
中科院分区：
文献类型：
--
作者：
Mu, Ying;Jia, Dongling;Wu, Hai-Long
开发快速、灵敏的葡萄糖检测传感器在食品工业、临床诊断、生物技术等领域具有重要意义。近年来，针对酶修饰电极不稳定、成本高、固定化过程复杂、操作条件苛刻等缺点，非酶修饰电极的研究备受关注。在碱性溶液中，纳米NiO修饰碳糊电极在高电位下的电位扫描过程大大增加了NiO衍生的氧化还原电对Ni（OH）（2）/NiOOH的数量，从而提高了电极的电化学性能和对葡萄糖氧化的电催化性能。非酶传感器对葡萄糖的响应速度快，响应时间小于5 s，表现出优异的电催化活性和检测性能。校准曲线在1-110 μ M的宽浓度范围内呈线性，灵敏度为43.9 nAh/μ M，相关系数为0.998。电极的检测限被认为是0.16 μ M的信噪比为3。所提出的非酶传感器可用于真实的样品中葡萄糖的测定。(C)2010爱思唯尔有限公司版权所有。
Development of fast and sensitive sensors for glucose determination is important in food industry, clinic diagnostics, biotechnology and many other areas. In these years, considerable attention has been paid to develop non-enzymatic electrodes to solve the disadvantages of the enzyme-modified electrodes, such as instability, high cost, complicated immobilization procedure and critical operating situation et al. Nano nickel oxide (NiO) modified non-enzymatic glucose sensors with enhanced sensitivity were investigated. Potential scanning nano NiO modified carbon paste electrodes up to high potential in alkaline solution greatly increases the amount of redox couple Ni(OH)(2)/NiOOH derived from NiO, and thus improves their electrochemical properties and electrocatalytical performance toward the oxidation of glucose. The nonenzymatic sensors response quickly to glucose and the response time is less than 5 s, demonstrating excellent electrocatalytical activity and assay performance. The calibration plot is linear over the wide concentration range of 1-110 mu M with a sensitivity of 43.9 nAh/mu M and a correlation coefficient of 0.998. The detection limit of the electrode was found to be 0.16 mu M at a signal-to-noise ratio of 3. The proposed non-enzymatic sensors can be used for the assay of glucose in real sample. (C) 2010 Elsevier B.V. All rights reserved.