Serum amyloid A (SAA) concentration varies among rheumatoid arthritis patients estimated by SAA/CRP ratio
Serum amyloid A (SAA) concentration varies among rheumatoid arthritis patients estimated by SAA/CRP ratio
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DOI：
10.1016/j.cccn.2005.04.006
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发表时间：
2005-10-01
影响因子：
5
通讯作者：
Yoshida, H
中科院分区：
文献类型：
--
作者：
Kokubun, M;Imafuku, Y;Yoshida, H
背景：C 反应蛋白 (CRP) 和血清淀粉样蛋白 A (SAA) 是类似的炎症敏感指标，但在几种疾病状况中存在差异。 SAA 水平通常较高，并且个体差异较大。评估SAA/CRP比值在SAA估计中的意义。方法：采用高灵敏乳胶凝集比浊免疫分析法对门诊类风湿性关节炎(RA)患者和健康受试者血清进行横断面和纵向测定CRP和SAA。根据CRP浓度将结果分为四组，并计算和评估SAA/CRP比值。 结果：在横断面研究中，CRP和SAA在RA患者血清中显示出显着相关，但在健康受试者中则不然。 SAA/CRP比值在RA患者中广泛存在，其范围趋于减小，根据CRP浓度观察到平均值。在纵向研究中，个体之间的比率变化很大，但个体内部的比率较小且相似。比率大小的差异是由于SAA浓度的差异造成的。结论：SAA/CRP比率的变化受SAA浓度的影响。在SAA评估中应检查该比率。 (c) 2005 Elsevier B.V. 保留所有权利。
Background: C reactive protein (CRP) and serum amyloid A (SAA) are similarly sensitive indicators of inflammation, but discrepancies are recognized in several disease conditions. SAA levels are generally higher and vary more among individuals. The significance of the SAA/CRP ratio was evaluated in the estimation of SAA.Methods: Sera of out-patients with rheumatoid arthritis (RA) and healthy subjects were measured for CRP and SAA cross-sectionally and longitudinally by a highly sensitive latex agglutination turbidimetric imununoassay. The results were classified into four groups according to the CRP concentration, and the SAA/CRP ratios were calculated and evaluated.Results: In the cross-sectional study, CRP and SAA were shown to correlate significantly in sera of patients with RA, but not in healthy subjects. The SAA/CRP ratios were wide RA patients and tended to decrease in the range and mean values were observed depending on the concentration of CRP. In the longitudinal study, variations of the ratio among individuals were wide, but smaller and similar within individuals. The difference in magnitude of the ratios is due to the difference in SAA concentration.Conclusion: Variations of SAA/CRP ratios were affected by SAA concentrations. The ratio should be checked in the evaluation of SAA. (c) 2005 Elsevier B.V. All rights reserved.