ASSESSMENT OF THE ROLE OF NONHEME-IRON AVAILABILITY IN IRON BALANCE
ASSESSMENT OF THE ROLE OF NONHEME-IRON AVAILABILITY IN IRON BALANCE
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DOI：
10.1093/ajcn/54.4.717
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发表时间：
1991-10-01
影响因子：
7.1
通讯作者：
LYNCH, SR
中科院分区：
文献类型：
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作者：
COOK, JD;DASSENKO, SA;LYNCH, SR
为了评估使用外源性标签单餐的吸收研究的营养相关性，我们开发了一种测量饮食中非血红素铁吸收的方法，并将结果与单餐的吸收进行了比较。当受试者食用他们通常的饮食时，饮食吸收(6.4%)与实验室喂养的代表性单餐(6.1%)有很好的一致性。通过结合促进剂和抑制剂的影响的模型估计的非血红素铁的利用率，与单餐的吸收显著相关，但与饮食吸收无关。当饮食被修改为最大限度地促进铁吸收时，饮食吸收仅略有增加(8.0%)，且仍显著低于单餐(13.5%)。在节制饮食的情况下，单餐吸收的减少同样被夸大了。这些结果表明，在西方饮食多样化的背景下，非血红素铁的生物利用度没有单餐吸收研究所显示的那么重要。
To assess the nutritional relevance of absorption studies that use extrinsically labeled single meals, we developed a method for measuring nonheme-iron absorption from the diet and compared the results with absorption from single meals. When subjects consumed their usual diet, there was good agreement between dietary absorption (6.4%) and representative single meals fed in the laboratory (6.1%). Nonheme-iron availability, as estimated by a model that incorporated the effect of both enhancers and inhibitors, correlated significantly with absorption from single meals but not with dietary absorption. When the diet was modified to promote iron absorption maximally, dietary absorption increased only slightly (8.0%) and remained significantly lower than it was from single meals (13.5%). With an inhibitory diet, the decrease in absorption from single meals was similarly exaggerated. These results indicate that in the context of a varied Western diet, nonheme-iron bioavailability is less important than absorption studies with single meals would suggest.