Protective efficacy of a live attenuated anti-coccidial vaccine administered to 1-day-old chickens
Protective efficacy of a live attenuated anti-coccidial vaccine administered to 1-day-old chickens
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DOI：
10.1080/10307945031000097912
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发表时间：
2003-06-01
期刊：
影响因子：
2.8
通讯作者：
Francis, MJ
中科院分区：
文献类型：
--
作者：
Crouch, CF;Andrews, SJ;Francis, MJ
通过评估对毒力攻击后体重增加变化的保护作用，研究了1日龄雏鸡接种减毒抗球虫活疫苗Paracox-5的效力。28天后，用每种组分种属（堆型艾美球虫、巨型艾美球虫、缓型艾美球虫或柔嫩艾美球虫）对接种疫苗的鸡进行独立攻毒，证明了对体重增加和病变形成相关减少的保护作用。此外，在接种疫苗后，还观察到在饲料转化率方面的禽类性能改善。此外，在设计为更接近模拟田间条件并使用孵化场喷雾给药的条件下，在接种后21天内，在一群肉鸡中均匀证明了对“种禽”引入的混合毒性攻毒的保护。这些数据表明，Paracox-5疫苗可保护肉鸡免受艾美耳球虫属引起的生产性能不良影响。
The efficacy of a live attenuated anti-coccidial vaccine, Paracox-5, administered to 1-day-old chicks was investigated by assessing protection against changes in weight gain following virulent challenge. Vaccinated birds were challenged independently 28 days later with each of the component species ( Eimeria acervulina, Eimeria maxima, Eimeria mitis or Eimeria tenella ), and protection was demonstrated against associated reduction in weight gain and lesion formation. In addition, an improvement in bird performance, in terms of feed conversion ratio, was also observed following vaccination. Furthermore, under conditions designed to more closely mimic those in the field and using hatchery spray administration, protection against a mixed virulent challenge introduced by 'seeder birds' was demonstrated evenly across a flock of broiler birds within 21 days after vaccination. These data demonstrate that Paracox-5 vaccine will protect broiler chickens against the adverse effects on performance induced by Eimeria spp.