Learning from cancer how to defeat bacteria.
Learning from cancer how to defeat bacteria.
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从癌症中学习如何击败细菌。
DOI：
10.1073/pnas.1222882110
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发表时间：
2013
影响因子：
11.1
通讯作者：
Ben-Jacob,Eshel
中科院分区：
文献类型：
--
作者：
Onuchic,JoséN;Jennings,PatriciaA;Ben-Jacob,Eshel
在土壤中发现了多种多样的微生物。在这个高度竞争的栖息地中，物种之间既有合作也有对抗。在进化过程中，土壤细菌已经发展出使用各种化学武器生存的复杂策略。这些毒素为潜在的抗生素提供了丰富的来源，也为设计新的抗微生物剂提供了支架。然而，抗生素的大量使用在全球范围内造成了一个重大的健康问题：细菌对抗生素的耐药性越来越强。细菌是当今医院的三大杀手之一。一个主要的问题是革兰氏阴性菌迅速对新抗生素产生多药耐药性的能力。
A rich variety of microorganisms are found in soil. Life in this highly competitive habitat involves both cooperative and antagonistic interactions between species. Over the course of evolution, soil bacteria have developed sophisticated strategies using a wide variety of chemical weapons to survive. These toxins provide rich sources of potential antibiotics, as well as scaffolds for the design of new antimicrobial agents. However, the massive use of antibiotics has created a major health problem worldwide: bacteria are becoming increasingly resistant to antibiotics (1). Bacteria are one of the top three killers in hospitals today. A major concern is the notorious ability of Gram-negative bacteria to rapidly develop multidrug resistance to new antibiotics.