HORMONAL CHANGES IN SERUM IN YOUNG MEN DURING PROLONGED PHYSICAL STRAIN
HORMONAL CHANGES IN SERUM IN YOUNG MEN DURING PROLONGED PHYSICAL STRAIN
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DOI：
10.1007/bf00421452
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发表时间：
1978-01-01
影响因子：
3
通讯作者：
FONNUM, F
中科院分区：
文献类型：
--
作者：
AAKVAAG, A;SAND, T;FONNUM, F
在为期5天的战斗过程中，对包括睡眠不足在内的严重体力紧张的陆军人员进行了内分泌反应的研究。血清中的甲状腺素（T4）浓度在前24小时内增加，然后以相当于7.6天半衰期的速率下降，并在第6天达到最低水平，55 ng/ml。三碘甲状腺原氨酸（T3）显示了类似的模式，虽然在第一个24小时内的增加不能证明。疗程结束后48 h内T4恢复正常，T3明显低于疗程前水平（P < 0.05）。血清促甲状腺激素（TSH）水平在治疗过程中受到抑制。血清催乳素水平在病程中明显受到抑制，而生长激素水平明显升高，两者之间呈显著负相关（r [相关系数] = -0.6）。与先前的报告一致，在第5天，血清睾酮水平迅速持续抑制至平均水平1.1 ng/ml。短时间睡眠（3-6小时）可有效逆转上述变化，尤其是生长激素、催乳素和睾酮。
The endocrine response to severe physical strain including lack of sleep was investigated in army personnel during a combat course of 5 days'' duration. The thyroxine (T4) concentration in serum increased during the first 24 h, and then declined at a rate corresponding to a half-life of 7.6 days and on day 6 reached the lowest level, 55 ng/ml. Triiodothyronine (T3) displayed a similar pattern, although an increase during the first 24 h could not be demonstrated. Within 48 h after the course T4 had returned to normal, whereas the serum level of T3 was significantly below the level before the course (P < 0.05). The serum level of TSH [thyrotropin] was suppressed during the course. The serum level of prolactin was significantly suppressed and growth hormone was markedly elevated during the course with a significant negative correlation (r [correlation coefficient] = -0.6) between the two. In agreement with a previous report, there was a rapid and sustained suppression of the serum level of testosterone to a mean level of 1.1 ng/ml on day 5. Short periods of sleep (3-6 h) were effective in reversing the described changes, especially for growth hormone, prolactin and testosterone.