A data resource from concurrent intracranial stimulation and functional MRI of the human brain.
A data resource from concurrent intracranial stimulation and functional MRI of the human brain.
复制标题
来自并发颅内刺激和人脑功能 MRI 的数据资源。
DOI：
10.1038/s41597-020-00595-y
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发表时间：
2020
期刊：
影响因子：
9.8
通讯作者：
Adolphs,R
中科院分区：
文献类型：
--
作者：
Thompson,WH;Nair,R;Oya,H;Esteban,O;Shine,JM;Petkov,CI;Poldrack,RA;Howard,M;Adolphs,R
绘制一个大脑区域对另一个大脑区域的因果影响是神经科学中的一个具有挑战性的问题，我们通过对大脑功能进行侵入性直接操作以及同时对所产生的影响进行全脑测量来解决这个问题。在这里，我们建立了一个独特的资源，并提供了 26 名在功能磁共振成像 (es-fMRI) 过程中接受电刺激的人类患者的数据。这些患者患有难治性癫痫，需要通过手术在皮质和皮质下位置植入颅内电极。刺激这些电极上的一个或多个接触点，同时以块设计记录 BOLD-fMRI 活动。对于具有不同刺激部位的患者，存在多次运行。我们描述了资源、数据收集过程、使用 fMRIPrep 分析管道进行预处理和伪影管理，并提供最终用户分析以可视化由特定部位电刺激产生的远端大脑激活。这些数据根据脑成像数据结构 (BIDS) 规范进行组织，可用于 openneuro.org 上的分析或未来数据集贡献，包括原始数据和预处理数据。
Mapping the causal effects of one brain region on another is a challenging problem in neuroscience that we approached through invasive direct manipulation of brain function together with concurrent whole-brain measurement of the effects produced. Here we establish a unique resource and present data from 26 human patients who underwent electrical stimulation during functional magnetic resonance imaging (es-fMRI). The patients had medically refractory epilepsy requiring surgically implanted intracranial electrodes in cortical and subcortical locations. One or multiple contacts on these electrodes were stimulated while simultaneously recording BOLD-fMRI activity in a block design. Multiple runs exist for patients with different stimulation sites. We describe the resource, data collection process, preprocessing using the fMRIPrep analysis pipeline and management of artifacts, and provide end-user analyses to visualize distal brain activation produced by site-specific electrical stimulation. The data are organized according to the brain imaging data structure (BIDS) specification, and are available for analysis or future dataset contributions on openneuro.org including both raw and preprocessed data.