Demographic and occupational determinants of anti-SARS-CoV-2 IgG seropositivity in hospital staff
Demographic and occupational determinants of anti-SARS-CoV-2 IgG seropositivity in hospital staff
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DOI：
10.1093/pubmed/fdaa199
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发表时间：
2022-06-27
影响因子：
4.4
通讯作者：
Pareek, Manish
中科院分区：
文献类型：
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作者：
Martin, Christopher A.;Patel, Prashanth;Pareek, Manish
背景尽管有证据表明，包括少数民族在内的人口统计学特征增加了感染严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）的风险，但尚不清楚这些特征与职业因素是否会影响医院工作人员的抗SARS-CoV-2 IgG血清阳性率。方法我们进行了横断面监测，检查莱斯特大学医院（UHL）NHS信托工作人员中的抗SARS-CoV-2 IgG血清阳性率。我们量化了按种族、职业和从业者资历分层的血清阳性率，并使用逻辑回归分析了与血清阳性相关的人口统计学和职业因素。结果10662名医务人员中1148人（10.8%）血清学阳性。与白色工作人员（血清阳性率9.1%）相比，南亚裔（12.3%）和黑人（21.2%）工作人员的血清阳性率较高。血清阳性率最高的职业和科室分别为护士/保健助理（13.7%）和急诊科（艾德）/急性内科（17.5%）。血清阳性率随着医疗/护理从业人员的资历而下降。经校正分析，少数民族与血清阳性相关（南亚人：aOR 1.26; 95%CI：1.07-1.49和黑人：2.42; 1.90-3.09）。麻醉师/ICU工作人员血清学阳性的可能性低于艾德/急性内科工作人员（0.41; 0.27-0.61）。结论种族、专业、工龄等职业因素与SARS冠状病毒2型抗体阳性率相关。这些发现可用于为一线医疗保健工作者提供职业风险评估。
Background Although evidence suggests that demographic characteristics including minority ethnicity increase the risk of infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), it is unclear whether these characteristics, together with occupational factors, influence anti-SARS-CoV-2 IgG seroprevalence in hospital staff. Methods We conducted cross-sectional surveillance examining seroprevalence of anti-SARS-CoV-2 IgG amongst staff at University Hospitals of Leicester (UHL) NHS Trust. We quantified seroprevalence stratified by ethnicity, occupation and seniority of practitioner and used logistic regression to examine demographic and occupational factors associated with seropositivity. Results A total of 1148/10662 (10.8%) hospital staff members were seropositive. Compared to White staff (seroprevalence 9.1%), seroprevalence was higher in South Asian (12.3%) and Black (21.2%) staff. The occupations and department with the highest seroprevalence were nurses/healthcare assistants (13.7%) and the Emergency Department (ED)/Acute Medicine (17.5%), respectively. Seroprevalence decreased with seniority in medical/nursing practitioners. Minority ethnicity was associated with seropositivity on an adjusted analysis (South Asian: aOR 1.26; 95%CI: 1.07-1.49 and Black: 2.42; 1.90-3.09). Anaesthetics/ICU staff members were less likely to be seropositive than ED/Acute medicine staff (0.41; 0.27-0.61). Conclusions Ethnicity and occupational factors, including specialty and seniority, are associated with seropositivity for anti-SARS-Cov-2 IgG. These findings could be used to inform occupational risk assessments for front-line healthcare workers.