Traditional Chinese medicine Dingkun Pill facilitates uterine receptivity for implantation in mice
Traditional Chinese medicine Dingkun Pill facilitates uterine receptivity for implantation in mice
复制标题
中药定坤丸促进小鼠子宫容受性着床
DOI：
10.1093/biolre/ioz141
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发表时间：
2019-10-01
影响因子：
3.6
通讯作者：
Kong, Shuangbo
中科院分区：
文献类型：
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作者：
Huang, Lin;Wang, Lemeng;Kong, Shuangbo
定坤丸是具有代表性的中药之一，用于妇科疾病的治疗已有数百年的历史。累积的观察和证据表明，DK的有益作用，包括增强下丘脑-垂体-卵巢轴的功能。然而，潜在的机制仍然难以捉摸。本研究通过一系列不同小鼠模型的研究，探讨了DK对子宫容受性和着床的影响。结果表明，DK可以通过影响雌激素靶基因的表达来提前胚胎着床时间，促进胚胎着床。在延迟着床小鼠模型中，在次优雌激素存在的情况下，DK能有效激活胚胎着床。我们进一步的研究表明，DK对植体相关基因的差异调控可能是DK对植体接受性建立的改善。本研究提供了DK在胚胎着床中的分子机制，有利于DK在人类生殖改善方面的潜在临床应用。丁香坤丸（DK）是具有代表性的中药之一，通过提高雌激素敏感性，促进子宫接受性的建立。
Dingkun Pill (DK) is one of the representative traditional Chinese medicines, which has been used in the treatment of gynecological diseases for hundreds of years. Accumulative observations and evidence have shown the beneficial effects of DK, including enhancing the function of hypothalamic-pituitary-ovarian axis. However, the underlying mechanisms remain elusive. In this study, the effects of DK on uterine receptivity and implantation were explored by a series of studies with different mouse models. The results showed that DK can advance the time of implantation by influencing the expression of estrogen target genes to facilitate embryo implantation. DK was efficient to activate embryo implantation at the presence of suboptimal estrogen in delayed implantation mouse model. Our further study revealed that the improvement of DK on receptivity establishment is attributed to the differential regulation of DK on implantation-associated genes. This study provides previously unappreciated molecular mechanism of DK in embryo implantation and benefits the potential clinical application of DK in human reproduction improvement.Summary SentenceDingkun Pill (DK), one of the representative traditional Chinese medicines, facilitates the establishment of uterine receptivity through enhancing the estrogen sensitivity.