Family growth: the eukaryotic DNA polymerase revolution.
Family growth: the eukaryotic DNA polymerase revolution.
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DOI：
10.1007/s00018-002-8405-y
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
K. Bebenek;T. Kunkel
中科院分区：
文献类型：
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作者：
K. Bebenek;T. Kunkel
在过去的几年里，随着许多具有显着特性的DNA聚合酶的发现，我们对复制和维持基因组所需的DNA交易的丰富复杂性的认识急剧增长。历史上，哺乳动物DNA聚合酶已经用希腊字母表的字母命名。当DNA聚合酶a在40多年前被发现时，它被认为是负责复制人类基因组60亿个核苷酸的聚合酶。事情发生了多么大的变化啊！我们现在知道，人类细胞含有十几种不同的DNA聚合酶，属于四个不同的家族（A，B，X和Y），基于se-
Our appreciation of the rich complexity of DNA transactions needed to replicate and maintain genomes has grown dramatically in the past few years with the discovery of a number of DNA polymerases that have remarkable properties. Historically, mammalian DNA polymerases have been designated with letters of the Greek alphabet. When DNA polymerase a was discovered more than four decades ago, it was thought to be THE polymerase responsible for replicating the six billion nucleotides of the human genome. How things have changed! We now know that human cells contain more than a dozen distinct DNA polymerases belonging to four different families (A, B, X, and Y) based on se-