Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second.
Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second.
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DOI：
10.1364/oe.18.020029
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发表时间：
2010-09-13
期刊：
影响因子：
3.8
通讯作者：
Fujimoto JG
中科院分区：
文献类型：
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作者：
Potsaid B;Baumann B;Huang D;Barry S;Cable AE;Schuman JS;Duker JS;Fujimoto JG
我们使用短腔扫频激光以 100,000–400,000 轴向扫描速率演示超高速扫频源/傅里叶域眼科 OCT 成像。几种设计配置说明了成像速度、灵敏度、轴向分辨率和成像深度之间的权衡。可变速率 A/D 光学时钟用于以 100kHz 轴向扫描速率采集线性 k OCT 条纹数据，组织中轴向分辨率为 5.3um。 1 GSPS 的固定速率采样可在组织中实现 7.5 毫米的成像范围，在 100 kHz 轴向扫描速率下具有 6.0 微米的轴向分辨率。通过缓冲激光扫描，可在 4mm 成像范围内实现 200kHz 轴向扫描速率和 5.3um 轴向分辨率。使用两个平行干涉仪的双点 OCT 可实现 400kHz 轴向扫描速率，几乎比以前的 1050nm 眼科结果快 2 倍，比当前商用仪器快 20 倍。显示出卓越的灵敏度滚降性能。成像在人类视网膜和眼前节中得到证实。宽视野 12×12mm 数据集包括黄斑和视神经乳头。小面积、高密度成像显示单个视锥细胞光感受器。 7.5mm 成像范围配置可以在单个图像中显示角膜、虹膜和前晶状体。成像速度和深度范围的这些改进为眼科成像提供了重要的优势。在宽视场内快速采集 3D-OCT 数据的能力有望简化检查方案。精细结构成像的能力可以提供有关病灶病理的详细信息。 1050nm 波长下的大成像范围和改进的图像穿透力有望提高对视网膜和前眼成像的仪器的性能。这些优点表明，1050nm 波长的扫频 OCT 将在未来的眼科仪器中发挥重要作用。
We demonstrate ultrahigh speed swept source/Fourier domain ophthalmic OCT imaging using a short cavity swept laser at 100,000–400,000 axial scan rates. Several design configurations illustrate tradeoffs in imaging speed, sensitivity, axial resolution, and imaging depth. Variable rate A/D optical clocking is used to acquire linear-in-k OCT fringe data at 100kHz axial scan rate with 5.3um axial resolution in tissue. Fixed rate sampling at 1 GSPS achieves a 7.5mm imaging range in tissue with 6.0um axial resolution at 100kHz axial scan rate. A 200kHz axial scan rate with 5.3um axial resolution over 4mm imaging range is achieved by buffering the laser sweep. Dual spot OCT using two parallel interferometers achieves 400kHz axial scan rate, almost 2X faster than previous 1050nm ophthalmic results and 20X faster than current commercial instruments. Superior sensitivity roll-off performance is shown. Imaging is demonstrated in the human retina and anterior segment. Wide field 12×12mm data sets include the macula and optic nerve head. Small area, high density imaging shows individual cone photoreceptors. The 7.5mm imaging range configuration can show the cornea, iris, and anterior lens in a single image. These improvements in imaging speed and depth range provide important advantages for ophthalmic imaging. The ability to rapidly acquire 3D-OCT data over a wide field of view promises to simplify examination protocols. The ability to image fine structures can provide detailed information on focal pathologies. The large imaging range and improved image penetration at 1050nm wavelengths promises to improve performance for instrumentation which images both the retina and anterior eye. These advantages suggest that swept source OCT at 1050nm wavelengths will play an important role in future ophthalmic instrumentation.