Factors Associated With Responsiveness to Gait and Balance Training in People With Parkinson Disease
Factors Associated With Responsiveness to Gait and Balance Training in People With Parkinson Disease
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DOI：
10.1097/npt.0000000000000246
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发表时间：
2019-01-01
影响因子：
3.8
通讯作者：
Franzen, Erika
中科院分区：
文献类型：
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作者：
Lofgren, Niklas;Conradsson, David;Franzen, Erika
背景和目的：尽管越来越多的证据支持运动对帕金森病（PwPD）患者有益，但鉴于疾病的异质性，目前尚不清楚给定的运动方式是否适合所有PwPD。本研究的目的是探讨与反应的一个高度挑战性的训练干预，包括双任务exercises.Methods：四十七PwPD（平均年龄：73岁，19名女性，Hoehn和Yahr阶段2-3）谁参加了10周的高度挑战性的步态和平衡训练的相关因素。基线人口统计学、疾病相关因素、身体和认知能力以及感知健康被用于预测平衡性能的百分比变化（Mini-BESTest）和舒适步态速度之间的评估前和评估后，使用多元线性回归分析。35%的平衡表现变化的方差是由一般健康感知解释的（beta =-0.36），定时起身和行动测试（beta = -0.33），以及认知任务的单任务表现（beta =-0.24）。49%的步态速度的变化是由步态速度解释，而执行双重任务（beta = -0.46），行走时的双任务干扰（beta = 0.43），完成定时启动测试的时间（beta = -0.29）和认知任务的错误百分比（beta = -0.25）.讨论和结论：研究结果可能表明，PwPD与整体较低的自觉健康，功能活动，和认知功能是最有可能受益于高度挑战性和注意力要求的步态和平衡训练。
Background and Purpose: Although increasing evidence supports the benefit-of exercise among peoplewith Parkinson disease (PwPD), it is unclear whether a given exercise modality suits all PwPD, given the heterogeneity of the disease. The purpose of this study was to explore factors associated with responsiveness to a highly challenging training intervention that incorporated dual-task exercises.Methods: Forty-seven PwPD (mean age: 73 years; 19 females, Hoehn and Yahr stages 2-3) who had participated in 10 weeks of highly challenging gait and balance training were included. Baseline demographics, disease-related factors, physical and cognitive ability, and perceived health were used for the prediction of percent change in balance performance (the Mini-BESTest) and comfortable gait speed between the pre-and postassessments, using multiple linear regression analyses.Results: Thirty-five percent of the variance of change in balance performance was explained by General Health Perceptions (beta =-0.36), the Timed Up and Go test (beta = -0.33), and the single-task performance of a cognitive task (beta =-0.24). Forty-nine percent of change in gait speed was explained by gait speed while performing a dual task (beta = -0.46), dual-task interference while walking (beta = 0.43), time to complete the Timed Up and Go test (beta = -0.29), and percent error on a cognitive task (beta = -0.25).Discussion and Conclusions: The results may suggest that the PwPD with overall lower perceived health, functional mobility, and cognitive functions are the ones most likely to benefit from highly challenging and attention-demanding gait and balance training.