Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory
Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory
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DOI：
10.1016/j.celrep.2019.09.044
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发表时间：
2019-10-29
期刊：
影响因子：
8.8
通讯作者：
Chevaleyre, Vivien
中科院分区：
文献类型：
--
作者：
Dominguez, Soledad;Rey, Christophe Clement;Chevaleyre, Vivien
青春期是一个易受伤害的时期，其特点是主要的认知变化。新的认知功能出现的潜在机制知之甚少。我们发现，一个长期抑郁症的抑制性传输（iLTD）从小白蛋白表达（PV+）的中间神经元在海马区角Ammonis 2（CA2）是不存在的年轻小鼠，但出现在青春期结束。我们证明，成熟的神经元周围网（PNN）和信号通过ErbB4是必需的这种可塑性。此外，我们证明，社会识别记忆显示相同的年龄依赖性iLTD和受损的有针对性的退化的PNN或iLTD封锁在CA2区。我们的数据揭示了一个不寻常的发展规则，可塑性在PV+中间神经元传输CA2区，并表明，这种可塑性参与了出现更高的认知功能，如社会记忆的形成，在青春期后期。
Adolescence is a vulnerable period characterized by major cognitive changes. The mechanisms underlying the emergence of new cognitive functions are poorly understood. We find that a long-term depression of inhibitory transmission (iLTD) from parvalbumin-expressing (PV+) interneurons in the hippocampal area Cornu Ammonis 2 (CA2) is absent in young mice but emerges at the end of adolescence. We demonstrate that the maturation of both the perineuronal net (PNN) and signaling through ErbB4 is required for this plasticity. Furthermore, we demonstrate that social recognition memory displays the same age dependence as iLTD and is impaired by targeted degradation of the PNN or iLTD blockade in area CA2. Our data reveal an unusual developmental rule for plasticity at the PV+ interneuron transmission in area CA2 and indicate that this plasticity is involved in the emergence of higher cognitive function, such as social memory formation, in late adolescence.