Ventral Midline Thalamus Is Necessary for Hippocampal Place Field Stability and Cell Firing Modulation
Ventral Midline Thalamus Is Necessary for Hippocampal Place Field Stability and Cell Firing Modulation
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DOI：
10.1523/jneurosci.2039-17.2017
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发表时间：
2018-01-03
影响因子：
5.3
通讯作者：
Poucet, Bruno
中科院分区：
文献类型：
--
作者：
Cholvin, Thibault;Hok, Vincent;Poucet, Bruno
丘脑腹侧中线的连合核（Re）和菱形核（Rh）与海马（Hip）和内侧前额叶皮质（mPFC）相连。越来越多的证据表明，这些核团可能在需要Hip-mPFC相互作用的认知过程中发挥关键作用，包括空间导航。在这里，我们测试了ReRh病变的影响，背海马CA 1位置细胞的放电特性和空间活动的雄性大鼠探索一个熟悉的或新的环境。我们发现，在熟悉的环境下，ReRh病变的CA 1位置细胞的空间特征没有变化。同样，在新环境中的第一次会议期间，空间相干性降低。然后，我们调查了现场的稳定性的位置细胞记录在5天内，在熟悉的和一个新的环境中提出了一个预定义的序列。虽然位置细胞的重新映射能力不受病变的影响，但我们的结果清楚地表明了ReRh大鼠两种环境的CA 1细胞表达的破坏。更具体地说，我们发现ReRh损伤产生（1）位置场稳定性的显著和持久的降低和（2）过度分散的强烈改变（即，点火可变性）。因此，在ReRh大鼠中，对新环境的探索似乎会干扰熟悉环境的表现，导致两种环境中的场稳定性降低。本研究表明，ReRh核的参与在长期的空间稳定性的CA 1的地方字段。
The reuniens (Re) and rhomboid (Rh) nuclei of the ventral midline thalamus are reciprocally connected with the hippocampus (Hip) and the medial prefrontal cortex (mPFC). Growing evidence suggests that these nuclei might play a crucial role in cognitive processes requiring Hip-mPFC interactions, including spatial navigation. Here, we tested the effect of ReRh lesions on the firing properties and spatial activity of dorsal hippocampal CA1 place cells as male rats explored a familiar or a novel environment. We found no change in the spatial characteristics of CA1 place cells in the familiar environment following ReRh lesions. Contrariwise, spatial coherence was decreased during the first session in a novel environment. We then investigated field stability of place cells recorded across 5 d both in the familiar and in a novel environment presented in a predefined sequence. While the remapping capacity of the place cells was not affected by the lesion, our results clearly demonstrated a disruption of the CA1 cellular representation of both environments in ReRh rats. More specifically, we found ReRh lesions to produce (1) a pronounced and long-lasting decrease of place field stability and (2) a strong alteration of overdispersion (i.e., firing variability). Thus, in ReRh rats, exploration of a novel environment appears to interfere with the representation of the familiar one, leading to decreased field stability in both environments. The present study shows the involvement of ReRh nuclei in the long-term spatial stability of CA1 place fields.