Exosome-Mediated Intercellular Communication Between Stellate Cells and Cancer Cells in Pancreatic Ductal Adenocarcinoma.
Exosome-Mediated Intercellular Communication Between Stellate Cells and Cancer Cells in Pancreatic Ductal Adenocarcinoma.
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DOI：
10.1097/mpa.0000000000000686
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发表时间：
2017-01
期刊：
影响因子：
2.9
通讯作者：
Waldron RT
中科院分区：
文献类型：
--
作者：
Lugea A;Waldron RT
胰腺导管腺癌（PDAC）长期以来被认为是复发性或未解决的炎症的结果，与肿瘤微环境内不同细胞类型之间的纤维化和广泛的交叉通讯有关。响应于损伤引起的胰腺损伤而产生的过多的细胞因子、趋化因子和DAMP（如TNF-α、IL-6、MCP-1、ATP和HMGB 1）引起炎症和纤维化反应。这些和其他因素有助于肿瘤微环境的复杂环境中的细胞间相互作用。然而，确切地说，哪些因子代表适当或不适当的信号，哪些细胞类型产生这些因子，以及对再生和恶性转化所协调的事件顺序的详细理解尚未解开。显然，迫切需要进一步了解不同细胞群与它们释放到微环境中的因子之间的因果关系。
Pancreatic ductal adenocarcinoma (PDAC) has long being viewed as a consequence of recurrent or unresolved inflammation, associated with fibrogenesis and extensive cross-communication between different cell types within the tumor microenvironment. A plethora of cytokines, chemokines and DAMPs such as TNF-α, IL-6, MCP-1, ATP and HMGB1, produced in response to pancreas damage from injury fuel inflammatory and fibrogenic responses. These and other factors contribute to the intercellular interplay within the complex milieu of the tumor microenvironment. However, precisely which factors represent appropriate or inappropriate signals, which cell type(s) produces the factors, and the detailed understanding of the sequence of events by which regeneration and malignant transformation are orchestrated have not yet been unraveled. Clearly, further understanding of cause-and effect relationships between the diverse cell populations and the factors they release into the microenvironment is urgently needed.