Diastereodivergent Intermolecular 1,2-Diamination of Unactivated Alkenes Enabled by Iodine Catalysis
Diastereodivergent Intermolecular 1,2-Diamination of Unactivated Alkenes Enabled by Iodine Catalysis
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DOI：
10.1021/jacs.1c00228
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发表时间：
2021-03-12
影响因子：
15
通讯作者：
Okumura, Sota
中科院分区：
文献类型：
--
作者：
Minakata, Satoshi;Miwa, Hayato;Okumura, Sota
本文报道了在碘催化剂作用下，由底物（氮源）控制的未活化烯烃的分子间反式和顺式-1，2-二胺化反应。这两种潜在方法的组合使用提供了获得所有非对映体形式的1，2-二胺的途径，尽管E-和Z-烯烃是可用的，并且所得产物可以容易地转化为游离的邻位二胺。
The stereospecific, substrate (nitrogen source)-controlled intermolecular anti- and syn-1,2-diaminations of unactivated alkenes using the same catalysis (an iodine catalyst) is reported. The combined use of the two potential methods provides access to all of the disastereomeric forms of 1,2-diamines in spite of the availability of E- and Z-alkenes, and the resulting products can be readily converted into free vicinal diamines.