αvβ3-integrin imaging:: a new approach to characterise angiogenesis?
αvβ3-integrin imaging:: a new approach to characterise angiogenesis?
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DOI：
10.1007/s00259-006-0136-0
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发表时间：
2006-07-01
影响因子：
9.1
通讯作者：
Haubner, Roland
中科院分区：
文献类型：
--
作者：
Haubner, Roland
概述：血管生成研究领域是发展最快的生物医学学科之一。人们正在努力开发用于治疗癌症以及非肿瘤疾病的抗血管生成药物。因此，成像技术允许相应的分子过程的非侵入性监测将是极大的兴趣。血管生成过程中涉及的一个目标结构是整合素α（v）β（3），它介导的血管形成过程中激活的内皮细胞的迁移。材料和方法：各种放射性标记的RGD肽已被引入使用核医学示踪剂techniques.Objectives：本综述讨论了示踪剂的发展和示踪剂优化的一些策略。它总结了临床前和临床数据，并讨论了这类示踪剂抑制血管生成的潜力。
Overview: The field of angiogenesis research is one of the most rapidly growing biomedical disciplines. Great efforts are being made to develop anti-angiogenesis drugs for treatment of cancer as well as non-oncological diseases. Thus, imaging techniques allowing non-invasive monitoring of corresponding molecular processes will be of great interest. One target structure involved in the angiogenic process is the integrin alpha(v)beta(3), which mediates the migration of activated endothelial cells during vessel formation.Materials and methods: A variety of radiolabelled RGD peptides have been introduced for monitoring of alpha(v)beta(3) expression using nuclear medicine tracer techniques.Objectives: This review discusses tracer development and highlights some strategies for tracer optimisation. It summarises the preclinical and clinical data and discusses the potential of this class of tracer to characterise angiogenesis.