Perspectives in clinical uses of high-intensity focused ultrasound
Perspectives in clinical uses of high-intensity focused ultrasound
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DOI：
10.1016/j.ultras.2004.04.003
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发表时间：
2004-08-01
期刊：
影响因子：
4.2
通讯作者：
Clement, GT
中科院分区：
文献类型：
--
作者：
Clement, GT
聚焦超声在大量的治疗应用中前景看好。高强度聚焦超声可以通过凝固性坏死杀死组织，这一点早已为人所知。然而，直到最近几年，随着高功率超声相控阵和无创监测方法的发展，临床实际应用才成为可能。这些技术与更复杂的治疗计划方法相结合，可以在大脑等曾经被认为无法触及的区域进行非侵入性聚焦。与此同时，在微气泡强化加热方面正在进行令人兴奋的研究，这种加热可以显著减少治疗时间。这些发展为医学研究提供了有价值的新工具，从而促进了潜在应用的数量的增加。本文提供了一个科学和工程的进步，使临床聚焦超声应用增长的概述。它还讨论了其中一些潜在的应用，包括治疗大脑疾病和靶向药物输送。(C)2004爱思唯尔B.V.保留所有权利。
Focused ultrasound holds promise in a large number of therapeutic applications. It has long been known that high intensity focused ultrasound can kill tissue through coagulative necrosis. However, it is only in recent years that practical clinical applications are becoming possible, with the development of high power ultrasound phased arrays and noninvasive monitoring methods. These technologies, combined with more sophisticated treatment planning methods allow noninvasive focusing in areas such as the brain, that were once thought to be unreachable. Meanwhile, exciting investigations are underway in microbubble-enhanced heating which could significantly reduce treatment times. These developments have promoted an increase in the number of potential applications by providing valuable new tools for medical research. This paper provides an overview of the scientific and engineering advances that are allowing the growth in clinical focused ultrasound applications. It also discusses some of these prospective applications, including the treatment of brain disorders and targeted drug delivery. (C) 2004 Elsevier B.V. All rights reserved.