Runxl promotes satellite cell proliferation during ischemia - Induced muscle regeneration
Runxl promotes satellite cell proliferation during ischemia - Induced muscle regeneration
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Runxl 在缺血期间促进卫星细胞增殖 - 诱导肌肉再生
DOI：
10.1016/j.bbrc.2018.08.083
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发表时间：
2018-09-18
影响因子：
3.1
通讯作者：
Li, Yangxin
中科院分区：
文献类型：
--
作者：
Bao, Meiyu;Liu, Songbai;Li, Yangxin
RUNX1 is a transcription factor that is not expressed in uninjured muscles, but can be detected in denervated muscles, suggesting a role of RUNX1 in muscle's response to injury. However, the role of RUNX1 in muscle's response to ischemia has not been reported. Our study showed that Runx1 is up regulated in skeletal muscle during ischemia reperfusion induced injury. Over-expression of Runx1 in C2C12 cells inhibits myogenic differentiation, but promotes proliferation of myoblasts. Consistent with these findings, we found that Runxl expression was decreased in differentiated satellite cells. Our results indicate that Runxl regulates muscle regeneration by promoting proliferation of satellite cells. (C) 2018 Elsevier Inc. All rights reserved.
