GENOMIC DIVERGENCE OF HIV-2 FROM GHANA
GENOMIC DIVERGENCE OF HIV-2 FROM GHANA
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DOI：
10.1089/aid.1989.5.593
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发表时间：
1989-12-01
影响因子：
1.5
通讯作者：
HAYAMI, M
中科院分区：
文献类型：
--
作者：
HASEGAWA, A;TSUJIMOTO, H;HAYAMI, M
人类免疫缺陷病毒1型（HIV-1）的遗传变异已被广泛研究，但HIV-2基因组的总核苷酸序列仅在两个菌株中被报道。对于HIV的系统发育分析，应该研究HIV-2的遗传变异性。本文报道了来自加纳的HIV-2分离物HIV-2[GH-1]的完整核苷酸序列。该病毒与HIV-2ROD的总核苷酸序列同源性约为85%。HIV-2[GH-1] gag和pol蛋白的氨基酸序列与HIV-2ROD具有90%的同源性，但其env基因和中心区域存在高度变异（氨基酸差异超过20%），表明HIV-2存在广泛的遗传异质性。然而，具有特定功能的序列在这些HIV-2分离株中相对保守。
Genetic variability in human immunodeficiency virus type 1 (HIV-1) has been studied extensively, but the total nucleotide sequence of the HIV-2 genome has been reported only in two strains. For phylogenetic analyses of HIV, the genetic variability of HIV-2 should be investigated. This paper reports the complete nucleotide sequence of an HIV-2 isolate from Ghana, HIV-2[GH-1]. This virus showed approximately 85% homology in overall nucleotide sequence with HIV-2ROD. The amino acid sequence of the gag and pol proteins of HIV-2[GH-1] showed 90% homology with those of HIV-2ROD, but its env gene and central regions were highly variable (more than 20% divergence in amino acids), indicating the presence of extensive genetic heterogeneity in HIV-2. However, the sequences with specific functions were relatively well conserved in these HIV-2 isolates.