Twisted growth and organization of cortical microtubules
Twisted growth and organization of cortical microtubules
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DOI：
10.1007/s10265-006-0039-y
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发表时间：
2007-01-01
影响因子：
2.8
通讯作者：
Hashimoto, Takashi
中科院分区：
文献类型：
--
作者：
Ishida, Takashi;Thitamadee, Siripong;Hashimoto, Takashi
在植物中，定向细胞扩张极大地促进了成熟细胞的最终形状，从而促进了器官结构。一种特别有趣的细胞扩增模式是螺旋生长，其中随着细胞生长，生长轴连续向右或向左倾斜。螺旋生长的固定手性提出了关于左右不对称的可能起源的基本问题。拟南芥的扭转突变体提供了独特的机会，研究螺旋生长的细胞基础。大多数具有固定手性的扭转突变体已被证明在微管功能上有缺陷，而在非固定方向上扭转的突变体似乎在生长素反应或运输上有缺陷。在微管功能受损的扭曲突变体中，已经发现皮质微管阵列的倾斜生长方向和排列之间存在良好的相关性。目前的挑战是要了解特定的阵列模式是如何组织在快速扩张的细胞的间期进展。对扭曲突变体的分子和细胞生物学研究将有助于更好地理解野生型植物细胞如何利用微管细胞骨架启动和严格维持直线生长。
In plants, directional cell expansion greatly contributes to the final shape of mature cells, and thus to organ architecture. A particularly interesting mode of cell expansion is helical growth in which the growth axis is continuously tilted either to the right or to the left as the cell grows. Fixed handedness of helical growth raises fundamental questions on the possible origin of left-right asymmetry. Twisting mutants of Arabidopsis thaliana offer unique opportunities to study the cellular basis of helical growth. Most of the twisting mutants with fixed handedness have been shown to have defects in microtubule functions, whereas mutants that twist in non-fixed directions appear to be defective in auxin response or transport. Good correlations have been found between the tilted growth direction and alignment of cortical microtubule arrays in twisting mutants with compromised microtubule functions. The present challenge is to understand how particular array patterns are organized during progression of the interphase in rapidly expanding cells. Molecular and cell biological studies on twisting mutants will lead to better understanding on how wildtype plant cells utilize the microtubule cytoskeleton to initiate and rigorously maintain straight growth.