PRENATAL AND POSTNATAL CHOLINE SUPPLEMENTATION PRODUCES LONG-TERM FACILITATION OF SPATIAL MEMORY
PRENATAL AND POSTNATAL CHOLINE SUPPLEMENTATION PRODUCES LONG-TERM FACILITATION OF SPATIAL MEMORY
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DOI：
10.1002/dev.420210405
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发表时间：
1988-05-01
影响因子：
2.2
通讯作者：
WILLIAMS, CL
中科院分区：
文献类型：
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作者：
MECK, WH;SMITH, RA;WILLIAMS, CL
虽然研究表明，成年大鼠记忆功能的短期改善可以发生在神经递质乙酰胆碱的前体的可用性增加时，很少有人知道成年大鼠的记忆功能是否可以通过在早期发育过程中补充前体而永久改变。在本研究中，雄性白化病大鼠在产前（通过妊娠大鼠饮食）和产后（皮下注射）暴露于胆碱氯补充剂。在60日龄时，在12臂和18臂径向迷宫任务中测试大鼠。结果表明，与对照同窝仔相比，围产期胆碱治疗的大鼠表现出更准确的性能的工作和参考记忆组件的任务。这种表现差异在第一阶段就很明显，并在整个训练过程中持续存在。进一步的分析表明，胆碱和对照组大鼠之间的差异不是由于使用不同的反应或线索使用策略。相反，胆碱诱导的表现差异似乎是由于长期的空间记忆能力和精度的增强。
Although research has demonstrated that short-term improvement in memory function of adult rats can occur when the availability of precursors for the neurotransmitter acetylcholine is increased, little is known about whether memory function of adult rats can be permanently altered by precursor supplementation during early development. In the present study, male albino rats were exposed to choline chlorine supplementation both prenatally (through the diet of pregnant rats) and postnatally (subcutaneous injections). At 60 days of age rats were tested on a 12- and 18-arm radial maze task. Results indicated that compared to control littermates, perinatalcholine-treated rats showed more accurate performance on both working and reference memory components of the task. This performance difference was apparent on the first block of sessions and continued throughout training. Further analysis revealed that the difference between choline and control rats is not due to use of differential response or cue-use strategies. Instead, it appears that choline induced performance differences are due to long-term enhancement of spatial memory capacity and precision.